未出血性脑动静脉畸形治疗研究
Management of unbled brain arteriovenous malformation study.
作者信息
Mohr J P, Yaghi Shadi
机构信息
Department of Neurology, Doris & Stanley Tananbaum Stroke Center, Neurological Institute, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA.
Department of Neurology, Doris & Stanley Tananbaum Stroke Center, Neurological Institute, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA.
出版信息
Neurol Clin. 2015 May;33(2):347-59. doi: 10.1016/j.ncl.2014.12.006.
In a recent trial limited to arteriovenous malformations discovered not to have bled, medical management was superior to medical management plus intervention. The trial was halted after 226 randomizations and a mean follow-up of 3.3 years owing to a disparity favoring the medical arm. Eligible patients were selected as suitable for lesion eradication. The initial sample size of 800 and follow-up plans for a mean of 7 years were lowered and shortened, respectively, by the outcome data. An application for extended follow-up was given poor priority scores owing to estimations that the disparities in outcomes would not change significantly.
在最近一项仅限于未出血的动静脉畸形的试验中，保守治疗优于保守治疗加干预。由于保守治疗组具有优势差异，该试验在226次随机分组和平均3.3年的随访后停止。符合条件的患者被选为适合病灶根除的对象。最初800例的样本量和平均7年的随访计划分别根据结果数据进行了下调和缩短。由于预计结果差异不会有显著变化，延长随访的申请获得的优先评分很低。
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