Zhu Shuang-Shuang, Zhou Shu-Lu, Zhou Chao-Min, Li Yong-Qiang, Zou He-Qun
Institute of Nephrology and Urology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2015 Apr;35(4):526-9.
To investigate the prevalence of PLA2R1 in renal biopsy specimens of patients with idiopathic membranous nephropathy (IMN) and explore the relationship between PLA2R1 and IMN.
A total of 108 adult patients with biopsy-proved glomerular diseases were enrolled in this study, including 41 with IMN, 2 with hepatitis B-associated membranous nephropathy, 8 with V lupus nephritis, 27 with IgA nephropathy, 19 with minimal change nephropathy, 5 with mild mesangial proliferative glomerulonephritis, and 6 with focal segmental glomeruloselerosis (FSGS). Indirect immunofluorescence assay was used to detect PLA2R1 in the biopsy specimens and the clinical variables of the IMN patients were analyzed.
In 35 of the 41 (85.37%) patients with IMN, PLA2R1 was detected with a fine granular pattern in the subepithelial deposits along the glomerular capillary loops. PLA2R1 antigen was not detected in patients with other glomerulopathies. No significant differences were found in age, serum creatinine, serum albumin, or 24-h urinary protein level between PLA2R1-positive and negative patients with IMN (P>0.05).
According to our results, 85.37% of adult patients with biopsy-proven IMN are positive for PLA2R1 antigen, which, however, does not contribute to variations of the patients' clinical manifestations.
研究特发性膜性肾病（IMN）患者肾活检标本中磷脂酶A2受体1（PLA2R1）的患病率，并探讨PLA2R1与IMN之间的关系。
本研究共纳入108例经活检证实的成人肾小球疾病患者，其中IMN患者41例，乙型肝炎相关性膜性肾病患者2例，Ⅴ型狼疮性肾炎患者8例，IgA肾病患者27例，微小病变肾病患者19例，轻度系膜增生性肾小球肾炎患者5例，局灶节段性肾小球硬化（FSGS）患者6例。采用间接免疫荧光法检测活检标本中的PLA2R1，并分析IMN患者的临床变量。
41例IMN患者中，35例（85.37%）在肾小球毛细血管袢上皮下沉积物中检测到呈细颗粒状的PLA2R1。其他肾小球疾病患者未检测到PLA2R1抗原。IMN患者中PLA2R1阳性与阴性患者在年龄、血清肌酐、血清白蛋白或24小时尿蛋白水平方面差异无统计学意义（P>0.05）。
根据我们的研究结果，85.37%经活检证实的成人IMN患者PLA2R1抗原呈阳性，然而，这对患者临床表现的差异并无影响。
