Wu Liqin, Li Zhixiong, Dai Yuanrong, Li Fengqin
Department of Respiratory Medicine, the Second Affiliated Hospital of Wenzhou Medical University, Zhejiang 325027, China.
Department of Respiratory Medicine, the Second Affiliated Hospital of Wenzhou Medical University, Zhejiang 325027, China. Email:
Zhonghua Jie He He Hu Xi Za Zhi. 2015 Feb;38(2):115-8.
To assess the variability of fractional exhaled nitric oxide (FeNO) and to explore the significances of FeNO in the diagnosis and treatment of asthma in pregnant women.
In a prospective study, 65 healthy pregnant women, 55 asthmatic non-pregnant women, 40 asthmatic pregnant women and 60 healthy non-pregnant women were enrolled in the study from Oct 2012 to Apr 2014.FeNO levels of the 4 groups were compared, and the variability of FeNO in different pregnancy periods of 15 healthy pregnant women were examined.We also analyzed the correlation between the level of FeNO, FEV1% pred, asthma control test (ACT) scores andblood eosinophils in patients of asthmatic pregnant women.
The difference in the levels of FeNO between healthy pregnant women (12 ± 6) ppb and healthy non-pregnant women (14 ± 5) ppb were no significant (t = 0.508, P > 0.05) . The levels of FeNO in different pregnancy periods of healthy pregnant women were not significantly different (F = 0.656, P > 0.05). Compared with healthy pregnant women (12 ± 6) ppb, the level of FeNO was significantly higher in asthmatic pregnant patients (43 ± 21) ppb (t = 2.981, P < 0.05) , but the difference of the levels of FeNO between asthmatic non-pregnant (51 ± 32) ppb and pregnant patients (43 ± 21) ppb were no significant (t = 0.366, P > 0.05) . There was no significant correlation between FeNO level and FEV1% pred (r = 0.164, P > 0.05), nor between FeNO level and ACT scores (r = 0.272, P > 0.05) , but there was significant correlation between FeNO level and eosinophils (r = 0.723, P < 0.05).
FeNO level is not influenced by pregnancy and different gestation periods.FeNO level in asthmatic pregnant women is increased, and FeNO is an important examination in the diagnosis of asthma during pregnancy.
评估呼出一氧化氮分数（FeNO）的变异性，并探讨FeNO在孕妇哮喘诊断和治疗中的意义。
在一项前瞻性研究中，2012年10月至2014年4月纳入了65名健康孕妇、55名非哮喘非孕妇、40名哮喘孕妇和60名健康非孕妇。比较4组的FeNO水平，并检测15名健康孕妇不同孕期FeNO的变异性。我们还分析了哮喘孕妇患者中FeNO水平、FEV1%预计值、哮喘控制测试（ACT）评分和血液嗜酸性粒细胞之间的相关性。
健康孕妇（12±6）ppb与健康非孕妇（14±5）ppb的FeNO水平差异无统计学意义（t = 0.508，P>0.05）。健康孕妇不同孕期的FeNO水平差异无统计学意义（F = 0.656，P>0.05）。与健康孕妇（12±6）ppb相比，哮喘孕妇患者的FeNO水平显著更高（43±21）ppb（t = 2.981，P<0.05），但非哮喘非孕妇（51±32）ppb与哮喘孕妇（43±21）ppb的FeNO水平差异无统计学意义（t = 0.366，P>0.05）。FeNO水平与FEV1%预计值之间无显著相关性（r = 0.164，P>0.05），与ACT评分之间也无显著相关性（r = 0.272，P>0.05），但FeNO水平与嗜酸性粒细胞之间存在显著相关性（r = 0.723，P<0.05）。
FeNO水平不受妊娠及不同孕期的影响。哮喘孕妇的FeNO水平升高，FeNO是孕期哮喘诊断的重要检查项目。
