Suppr超能文献

一种用于对化学危害-食品组合进行优先级排序的风险管理工具的开发及对选定霉菌毒素的论证

Development of a risk management tool for prioritizing chemical hazard-food pairs and demonstration for selected mycotoxins.

作者信息

Stornetta Alessia, Engeli Barbara E, Zarn Jürg A, Gremaud Gérard, Sturla Shana J

机构信息

ETH Zürich, Department of Health Sciences and Technology, Schmelzbergstrasse 9, 8092 Zürich, Switzerland.

Federal Food Safety and Veterinary Office FSVO, 8004 Zürich, Switzerland.

出版信息

Regul Toxicol Pharmacol. 2015 Jul;72(2):257-65. doi: 10.1016/j.yrtph.2015.04.014. Epub 2015 Apr 20.

Abstract

We developed a simple tool for ranking chemical hazard-food pairs to assist policy makers and risk managers selecting the hazard-food pairs that deserve more attention and need to be monitored during food safety inspections. The tool is based on the derivation of a "Priority Index" (PI) that results from the ratio of the potency of the hazard and the consumer exposure. The potency corresponds to a toxicity reference value of the hazard, whereas the exposure results from the combination of the concentration of the hazard in the food, and the food consumption. Tool's assumptions and limitations are demonstrated and discussed by ranking a dataset of 13 mycotoxins in 26 food items routinely analyzed in Switzerland. The presented ranking of mycotoxin-food pairs has to be considered as relative due to scarce exposure data availability, and uncertainties in toxicity reference values. However, this representative example allows demonstrating the simplicity and the ability of the PI tool to prioritize chemical hazard-food pairs.

摘要

我们开发了一种用于对化学危害-食品对进行排名的简单工具,以协助政策制定者和风险管理者选择那些在食品安全检查期间值得更多关注且需要监测的危害-食品对。该工具基于“优先级指数”(PI)的推导,该指数由危害的毒性和消费者暴露量的比值得出。毒性对应于危害的毒性参考值,而暴露量则由食品中危害的浓度与食品消费量的组合得出。通过对瑞士常规分析的26种食品中的13种霉菌毒素数据集进行排名,展示并讨论了该工具的假设和局限性。由于暴露数据稀缺以及毒性参考值存在不确定性,所呈现的霉菌毒素-食品对排名只能视为相对的。然而,这个具有代表性的例子展示了PI工具在对化学危害-食品对进行优先级排序方面的简单性和能力。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验