Fu Xiaoyong, Patel Dhruti, Zhu Hui, MacLennan Gregory, Wang Yves T, Jenkins Michael W, Rollins Andrew M
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 USA.
Department of Urology and Pathology, Case Western Reserve University, Cleveland, Ohio 44106 USA.
Biomed Opt Express. 2015 Mar 6;6(4):1164-71. doi: 10.1364/BOE.6.001164. eCollection 2015 Apr 1.
We demonstrate an ultrathin flexible cone-scanning forward-viewing OCT probe which can fit through the working channel of a flexible ureteroscope for renal pelvis imaging. The probe is fabricated by splicing a 200 µm section of core-less fiber and a 150 µm section of gradient-index (GRIN) fiber to the end of a single mode (SM) fiber. The probe is designed for common-path OCT imaging where the back-reflection of the GRIN fiber/air interface is used as the reference signal. Optimum sensitivity was achieved with a 2 degree polished probe tip. A correlation algorithm was used to correct image distortion caused by non-uniform rotation of the probe. The probe is demonstrated by imaging human skin in vivo and porcine renal pelvis ex vivo and is suitable for imaging the renal pelvis in vivo for cancer staging.
我们展示了一种超薄柔性锥形扫描前视光学相干断层扫描（OCT）探头，它可以穿过柔性输尿管镜的工作通道，用于肾盂成像。该探头是通过将一段200μm的无芯光纤和一段150μm的梯度折射率（GRIN）光纤拼接至单模（SM）光纤末端制成的。该探头专为共路OCT成像设计，其中GRIN光纤/空气界面的背向反射用作参考信号。2度抛光的探头尖端实现了最佳灵敏度。使用相关算法校正由探头不均匀旋转引起的图像失真。通过对人体皮肤进行体内成像和对猪肾盂进行离体成像展示了该探头，它适用于对肾盂进行体内成像以进行癌症分期。
