Doroftei Bogdan, Mambet Cristina, Zlei Mihaela
Obstetrics and Gynecology Department, Gr. T. Popa University of Medicine and Pharmacy, Iasi, Romania; Origyn Fertility Center, Iasi, Romania.
Synevo Central Laboratory-Medicover Group, Bucuresti, Romania.
PLoS One. 2015 Apr 24;10(4):e0125216. doi: 10.1371/journal.pone.0125216. eCollection 2015.
Wide regional differences in the age-related Anti Mullerian hormone (AMH) regression patterns or age at onset of natural menopause have been reported, possibly reflecting genetic, socioeconomic, environmental, racial or ethnic peculiarities. Moreover, adaptation of AMH levels from different assays using regression functions may lack accuracy and externally defined references for AMH levels may not fully comply with a specific geographical area. The current study aimed to establish an accurate mathematical relationship between AMH serum values and age in a large group of women from Romania, as any consistent difference from previously reported regression models may aid in building specific profiles for the AMH decline with age in this geographical region. Our study pointed out to the quadratic regression as the most fitted pattern of correlation for all the age groups between 24 and 45. To our knowledge the current manuscript is based on the singular study carried out in this geographical region, generating a particular age-related pattern of association between age and serum AMH levels in women, regardless of their subjacent pathologies.
据报道，与年龄相关的抗苗勒管激素（AMH）衰退模式或自然绝经开始年龄存在广泛的地区差异，这可能反映了遗传、社会经济、环境、种族或民族特点。此外，使用回归函数对不同检测方法的AMH水平进行调整可能缺乏准确性，并且外部定义的AMH水平参考值可能不完全适用于特定地理区域。本研究旨在在一大群罗马尼亚女性中建立AMH血清值与年龄之间的精确数学关系，因为与先前报道的回归模型存在的任何一致差异都可能有助于构建该地理区域内AMH随年龄下降的特定特征。我们的研究指出，二次回归是24至45岁所有年龄组最适合的相关模式。据我们所知，目前的手稿基于在该地理区域进行的唯一一项研究，得出了女性年龄与血清AMH水平之间特定的年龄相关关联模式，无论其潜在病理状况如何。
