CD4(+) CD44（极低表达）细胞是独特的外周前体细胞，与近期胸腺迁出细胞和干细胞样记忆细胞不同。
CD4(+) CD44(v.low) cells are unique peripheral precursors that are distinct from recent thymic emigrants and stem cell-like memory cells.
作者信息
Zhao Chunfang, Marrero Idania, Narsale Aditi, Moya Rosita, Davies Joanna D
机构信息
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, U.S.A.
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, U.S.A.
出版信息
Cell Immunol. 2015 Aug;296(2):106-14. doi: 10.1016/j.cellimm.2015.04.002. Epub 2015 Apr 17.
CD4(+) CD44(v.low) cells are peripheral precursor T cells that inhibit lymphopenia by generating a large CD4(+) T cell pool containing balanced numbers of naïve, memory, and regulatory Foxp3(+) cells with a diverse TCR repertoire. Recent thymic emigrants (RTE) and stem cell-like memory T cells (T(SCM)) can also replenish a T cell pool. In this study we formally test whether CD44(v.low) cells are the same population as RTE and T(SCM). Our data show that, in contrast to RTE, CD44(v.low) cells express high levels of CD45RB and low levels of CD24. Moreover, CD44(v.low) cells isolated from mice devoid of RTE retain their capacity to repopulate lymphopenic mice with naïve and memory cells and Foxp3(+) Tregs. In addition, CD44(v.low) cells do not express IL-2Rβ, Sca-1, and CXCR3, the phenotypic hallmarks of T(SCM). Overall, these data demonstrate that CD44(v.low) cells are neither RTE nor T(SCM).
CD4(+)CD44（极低表达）细胞是外周前体T细胞，它们通过生成一个包含数量平衡的初始、记忆和调节性Foxp3(+)细胞且具有多样化TCR库的大型CD4(+)T细胞池来抑制淋巴细胞减少。近期胸腺迁出细胞（RTE）和干细胞样记忆T细胞（T(SCM)）也可以补充T细胞池。在本研究中，我们正式测试了CD44（极低表达）细胞是否与RTE和T(SCM)为同一群体。我们的数据表明，与RTE不同，CD44（极低表达）细胞表达高水平的CD45RB和低水平的CD24。此外，从缺乏RTE的小鼠中分离出的CD44（极低表达）细胞保留了用初始细胞、记忆细胞和Foxp3(+)调节性T细胞（Treg）重新填充淋巴细胞减少小鼠的能力。此外，CD44（极低表达）细胞不表达IL-2Rβ、Sca-1和CXCR3，而这些是T(SCM)的表型特征。总体而言，这些数据表明CD44（极低表达）细胞既不是RTE也不是T(SCM)。
Zotero 插件