Broby-Johansen U, Kristensen J K
Clin Exp Dermatol. 1989 Jul;14(4):286-8. doi: 10.1111/j.1365-2230.1989.tb01981.x.
Ten patients with plaque-type psoriasis were treated by applying semi-permeable hydrocolloid dressings (Com-feel, Coloplast, Denmark) and the effect compared to untreated skin. The treatment effect was evaluated by: (a) O2-consumption as measured by a TCM-2 oxygen-monitor; (b) blood flow as measured by laser-Doppler flowmetry; (c) temperature measurements using thermocouples; (d) a clinical score. The treatment effect was evaluated after 1, 2 and 7 days and although there was a significant and sustained improvement in the clinical score following Day 7 (P less than 0.05), this was not associated with a significant change in any of the objective measurements during the study (P greater than 0.05). In the same patients the clinical effect of occlusion was evaluated after 21 days in another area. A pronounced effect was observed comparable to, equal to, or better than that of crude coal tar given as daily applications followed by bathing. There was no significant change in any of the parameters at the sites of untreated psoriasis.
十名斑块型银屑病患者接受了半透性水胶体敷料（丹麦康乐保公司生产的Com-feel）治疗，并将治疗效果与未治疗的皮肤进行比较。通过以下方式评估治疗效果：（a）使用TCM-2型氧气监测仪测量耗氧量；（b）使用激光多普勒血流仪测量血流量；（c）使用热电偶测量温度；（d）进行临床评分。在第1天、第2天和第7天后评估治疗效果，尽管在第7天后临床评分有显著且持续的改善（P小于0.05），但在研究期间任何客观测量指标均未出现显著变化（P大于0.05）。在同一批患者中，在另一个部位于21天后评估封包疗法的临床效果。观察到有明显效果，与每日涂抹粗煤焦油后沐浴的效果相当、相同或更好。未治疗的银屑病部位的任何参数均未出现显著变化。
