B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia.
作者信息
Zaborsky Nadja, Holler Claudia, Geisberger Roland, Asslaber Daniela, Gassner Franz Josef, Egger Viktoria, Piñón-Hofbauer Josephina, Kocher Thomas, Hartmann Tanja Nicole, Greil Richard, Egle Alexander
机构信息
Laboratory for Immunological and Molecular Cancer Research, 3 Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases and Rheumatology, Oncologic Center, Paracelsus Medical University Salzburg, Austria Salzburg Cancer Research Institute, Austria
Laboratory for Immunological and Molecular Cancer Research, 3 Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases and Rheumatology, Oncologic Center, Paracelsus Medical University Salzburg, Austria Salzburg Cancer Research Institute, Austria.
出版信息
Haematologica. 2015 Aug;100(8):e307-10. doi: 10.3324/haematol.2015.124719. Epub 2015 Apr 24.
Abstract
摘要
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Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study.定型B细胞受体免疫球蛋白在慢性淋巴细胞白血病中的临床疗效：一项回顾性多中心研究
Lancet Haematol. 2014 Nov;1(2):e74-84. doi: 10.1016/S2352-3026(14)00005-2. Epub 2014 Nov 3.
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Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia.在慢性淋巴细胞白血病中，来那度胺治疗可逆转化疗诱导的表达抑制性受体的T细胞增加。
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T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production.慢性淋巴细胞白血病（CLL）患者的 T 细胞表现出 T 细胞耗竭的特征，但保留细胞因子产生的能力。
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Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug.慢性淋巴细胞白血病T细胞表现出免疫突触形成受损，而这可以通过一种免疫调节药物逆转。
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