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B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia.

作者信息

Zaborsky Nadja, Holler Claudia, Geisberger Roland, Asslaber Daniela, Gassner Franz Josef, Egger Viktoria, Piñón-Hofbauer Josephina, Kocher Thomas, Hartmann Tanja Nicole, Greil Richard, Egle Alexander

机构信息

Laboratory for Immunological and Molecular Cancer Research, 3 Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases and Rheumatology, Oncologic Center, Paracelsus Medical University Salzburg, Austria Salzburg Cancer Research Institute, Austria

Laboratory for Immunological and Molecular Cancer Research, 3 Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases and Rheumatology, Oncologic Center, Paracelsus Medical University Salzburg, Austria Salzburg Cancer Research Institute, Austria.

出版信息

Haematologica. 2015 Aug;100(8):e307-10. doi: 10.3324/haematol.2015.124719. Epub 2015 Apr 24.

DOI:10.3324/haematol.2015.124719
PMID:25911550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5004431/
Abstract
摘要

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Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity.一线使用idelalisib治疗慢性淋巴细胞白血病会频繁引发免疫介导的肝毒性。
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本文引用的文献

1
Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study.定型B细胞受体免疫球蛋白在慢性淋巴细胞白血病中的临床疗效：一项回顾性多中心研究
Lancet Haematol. 2014 Nov;1(2):e74-84. doi: 10.1016/S2352-3026(14)00005-2. Epub 2014 Nov 3.
2
Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia.在慢性淋巴细胞白血病中，来那度胺治疗可逆转化疗诱导的表达抑制性受体的T细胞增加。
Haematologica. 2014 May;99(5):67-9. doi: 10.3324/haematol.2013.098459. Epub 2014 Feb 21.
3
The significance of stereotyped B-cell receptors in chronic lymphocytic leukemia.慢性淋巴细胞白血病中定型 B 细胞受体的意义。
Hematol Oncol Clin North Am. 2013 Apr;27(2):237-50. doi: 10.1016/j.hoc.2012.12.001.
4
T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production.慢性淋巴细胞白血病（CLL）患者的 T 细胞表现出 T 细胞耗竭的特征，但保留细胞因子产生的能力。
Blood. 2013 Feb 28;121(9):1612-21. doi: 10.1182/blood-2012-09-457531. Epub 2012 Dec 17.
5
Expansion of a CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression.早期 CLL 患者中 CD8(+)PD-1(+)复制性衰老表型的扩增与 CD4:CD8 比值倒置和疾病进展相关。
Clin Cancer Res. 2012 Feb 1;18(3):678-87. doi: 10.1158/1078-0432.CCR-11-2630. Epub 2011 Dec 21.
6
Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug.慢性淋巴细胞白血病T细胞表现出免疫突触形成受损，而这可以通过一种免疫调节药物逆转。
J Clin Invest. 2008 Jul;118(7):2427-37. doi: 10.1172/JCI35017.
7
Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia.慢性淋巴细胞白血病疾病严重程度和生存的临床及分子预测指标
Am J Hematol. 2007 Dec;82(12):1063-70. doi: 10.1002/ajh.20987.
8
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.未突变的免疫球蛋白重链（Ig V(H)）基因与一种侵袭性更强的慢性淋巴细胞白血病形式相关。
Blood. 1999 Sep 15;94(6):1848-54.
9
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.免疫球蛋白V基因（Ig V）突变状态和CD38表达作为慢性淋巴细胞白血病新的预后指标
Blood. 1999 Sep 15;94(6):1840-7.