Jaiman Sunil, Pochiraju Manjula, Gundabattula Sirisha Rao, Surampudi Kameswari, Narayana Rao Dama Venkata Lakshmi, Kandikattu Sreekanth
Fernandez Hospital, Hyderabad, India.
Fernandez Hospital, Hyderabad, India
Int J Surg Pathol. 2015 Sep;23(6):465-71. doi: 10.1177/1066896915583995. Epub 2015 Apr 24.
Endometriosis affects 4% to 13% of all women of reproductive age although its true incidence is unknown. The ability of endometriosis to transform into malignancy, first described by Sampson in 1925, is a rare occurrence affecting 1% of lesions with ovary being the primary site in 79%. The authors describe 3 premenopausal women without risk factors for malignancy presenting with ovarian and/or extraovarian endometrioid adenocarcinoma. All of them demonstrated features of pre-/coexisting endometriosis but malignancy was preoperatively suspected in only 1 instance. Postsurgical follow-up of the cases did not document any recurrence. The propensity for malignant conversion occurring in women 10 to 20 years younger vis-a-vis those affected by de novo ovarian cancer, destruction of the endometriotic foci, and underreporting vindicate close follow-up and scrutiny of women with endometriosis and ovarian endometriomas.
子宫内膜异位症影响4%至13%的育龄妇女，但其确切发病率尚不清楚。子宫内膜异位症转变为恶性肿瘤的能力，最早由桑普森于1925年描述，是一种罕见情况，1%的病变会发生恶变，其中79%以卵巢为主要部位。作者描述了3例无恶性肿瘤危险因素的绝经前女性，她们患有卵巢和/或卵巢外子宫内膜样腺癌。所有患者均表现出存在/并存子宫内膜异位症的特征，但术前仅1例怀疑有恶性肿瘤。对这些病例的术后随访未发现任何复发情况。相对于新发卵巢癌患者，年龄小10至20岁的女性发生恶性转化的倾向、子宫内膜异位病灶的破坏以及报告不足，都证明对子宫内膜异位症和卵巢子宫内膜瘤患者进行密切随访和仔细检查是合理的。
