Zu Hongliang, Wang Huiling, Li Chunfeng, Kang Yue, Xue Yingwei
Hepatogastroenterology. 2015 Jan-Feb;62(137):225-30.
BACKGROUND/AIMS: The prognostic value of age on patients with gastric cancer is not well defined. The aim of this retrospective study is to analyze the impact of age on survival in patients with gastric cancer.
A total of 1800 patients with gastric carcinoma, who had undergone gastrectomy between 1997-2007 years were included. They were divided into six different age groups (21-30, 31-40, 41-50, 51- 60, 61-70 and 71-80 years). We reviewed patient's clinico-pathological characteristics and the prognosis with special reference to their ages.
Among the six age groups, the younger patients have more female-dominated patients and poorly differentiated carcinoma, whereas the older patients have a higher incidence of large tumors (≥5 cm) and more patients with stage T3. Moreover, there were more liver metastases in the older age groups. Univariate analysis showed that there were significant differences in 5-year survival rates among the six age groups. Multivariate analysis confirmed age, tumor size, pT stage, pN stage and curability were independent prognostic factors.
There are several distinctive properties related to age of patients with gastric cancer, the older patients have more aggressive features and poorer prognosis than the younger patients.
背景/目的：年龄对胃癌患者的预后价值尚未明确界定。本回顾性研究的目的是分析年龄对胃癌患者生存的影响。
纳入1997年至2007年间接受胃切除术的1800例胃癌患者。他们被分为六个不同年龄组（21 - 30岁、31 - 40岁、41 - 50岁、51 - 60岁、61 - 70岁和71 - 80岁）。我们特别参照患者年龄回顾了临床病理特征和预后情况。
在六个年龄组中，较年轻患者中女性占比更多且低分化癌更多，而老年患者中肿瘤较大（≥5 cm）的发生率更高且T3期患者更多。此外，老年年龄组中肝转移更多。单因素分析显示六个年龄组的5年生存率存在显著差异。多因素分析证实年龄、肿瘤大小、pT分期、pN分期和可治愈性是独立的预后因素。
胃癌患者的年龄存在一些独特特征，老年患者比年轻患者具有更侵袭性的特征且预后更差。
