Bradshaw Pamela J, Stobie Paul, Knuiman Matthew W, Briffa Thomas G, Hobbs Michael S T
School of Population Health, The University of Western Australia, Australia.
Department of Cardiovascular Medicine, Sir Charles Gairdner Hospital, Australia.
Int J Cardiol. 2015;190:42-6. doi: 10.1016/j.ijcard.2015.04.099. Epub 2015 Apr 15.
Research suggests that survival among the recipients of a cardiac permanent pacemaker (PPM) matches the age- and sex-matched general population in the absence of cardiovascular disease. We used linked administrative data to examine life expectancy-based outcomes for adults requiring a cardiac PPM.
Population-level hospital admissions data were used to identify all recipients of an initial PPM during 1995-2008. Expected years of additional life remaining at the time of implantation were calculated for each patient from population life tables. Observed years were calculated using linked mortality data to end 2011. Cox regression was used to determine demographic and clinical predictors of survival.
In 8757 patients age-adjusted risk of death to 5 years was associated with male sex, higher Charlson Comorbidity Index score (excluding cardiac disease), a history of heart failure, cardiomyopathy or atrial fibrillation and emergency admission. Coronary revascularisation surgery reduced long-term risk. The observed/expected ratio of additional years of life was 0.80 for men and 0.84 for women overall, varying from 0.92 for women without significant comorbidity to 0.40 for patients with the highest Charlson score and cardiomyopathy. The oldest patients (80-99 years) did relatively well, probably reflecting patient selection. Heart disease was the most frequent cause of death.
Life expectancy among PPM recipients without significant comorbidity approached that of the general population. Greater non-cardiac comorbidity, heart failure, atrial fibrillation and, in particular, cardiomyopathy, contributed most to the loss of expected years of life in all age groups. The oldest patients and women did relatively well.
研究表明,在没有心血管疾病的情况下,心脏永久性起搏器(PPM)接受者的生存率与年龄和性别匹配的普通人群相当。我们使用关联的行政数据来研究需要心脏PPM的成年人基于预期寿命的结局。
使用人群水平的医院入院数据来识别1995年至2008年期间所有首次接受PPM的患者。根据人群生命表计算每位患者植入时剩余的预期额外寿命年数。使用关联的死亡率数据计算至2011年底的观察年数。采用Cox回归确定生存的人口统计学和临床预测因素。
在8757例患者中,5年年龄调整后的死亡风险与男性、较高的Charlson合并症指数评分(不包括心脏病)、心力衰竭病史、心肌病或心房颤动以及急诊入院有关。冠状动脉血运重建手术降低了长期风险。总体而言,男性额外寿命的观察/预期比为0.80,女性为0.84,无明显合并症的女性为0.92,Charlson评分最高且患有心肌病的患者为0.40。年龄最大的患者(80 - 99岁)表现相对较好,这可能反映了患者的选择情况。心脏病是最常见的死亡原因。
无明显合并症的PPM接受者的预期寿命接近普通人群。更大程度的非心脏合并症、心力衰竭、心房颤动,尤其是心肌病,在所有年龄组中对预期寿命损失的影响最大。年龄最大的患者和女性表现相对较好。