Department of Pharmacy, School of Pharmacy, Hanyang University, Ansan 426-791, Korea; Institute of Pharmacological Research, Hanyang University, Ansan 426-791, Korea.
Rajiv Gandhi Centre for Biotechnology, Thycaud P.O., Trivandrum 695 014, Kerala, India.
Trends Microbiol. 2015 Aug;23(8):479-89. doi: 10.1016/j.tim.2015.03.010. Epub 2015 Apr 24.
The analysis of the whole-genome sequences of Vibrio cholerae strains from previous and current cholera pandemics has demonstrated that genomic changes and alterations in phage CTX (particularly in the gene encoding the B subunit of cholera toxin) were major features in the evolution of V. cholerae. Recent studies have revealed the genetic mechanisms in these bacteria by which new variants of V. cholerae are generated from type-specific strains; these mechanisms suggest that certain strains are selected by environmental or human factors over time. By understanding the mechanisms and driving forces of historical and current changes in the V. cholerae population, it would be possible to predict the direction of such changes and the evolution of new variants; this has implications for the battle against cholera.
对先前和当前霍乱大流行期间分离的霍乱弧菌全基因组序列的分析表明，基因组变化和噬菌CTX 的改变（特别是编码霍乱毒素 B 亚单位的基因）是霍乱弧菌进化的主要特征。最近的研究揭示了这些细菌中产生霍乱弧菌新变体的遗传机制；这些机制表明，某些菌株会随着时间的推移被环境或人为因素选择。通过了解霍乱弧菌种群中历史和当前变化的机制和驱动力，就有可能预测此类变化的方向和新变体的进化；这对与霍乱的斗争具有重要意义。
