Burton M A, Gray B N, Klemp P F, Kelleher D K, Hardy N
University of Western Australia, Department of Surgery, Perth.
Eur J Cancer Clin Oncol. 1989 Oct;25(10):1487-91. doi: 10.1016/0277-5379(89)90109-0.
Selective internal radiation therapy for primary and secondary liver cancer involves the intra-hepatic arterial injection of microspheres containing yttrium-90. The microspheres become entrapped primarily in, and thus preferentially irradiate, tumour tissue. During a clinical trial with this therapy it has been possible to take tumour and normal liver tissue samples, after microsphere injection, and measure their specific activity. Absorbed tissue radiation doses were then calculated for tumour and normal tissue samples from a total of nine patients. The mean tumour to normal tissue ratio for radiation dose for the nine patients was approximately 6:1 with a range of 0.4:1-45:1. Injection of similar amounts of activity in different patients resulted in markedly differing tissue doses depending on liver size and tumour burden. Normal liver tissue doses of between 9 and 75 Gy were measured while corresponding tumour tissue doses ranged from 34 to 147 Gy. Selective internal radiation therapy, combined with the blood flow changes resulting from angiotensin II administration, can provide preferentially high radiation doses to tumour tissue within the liver whilst relatively sparing the surrounding normal liver tissue.
原发性和继发性肝癌的选择性体内放射治疗涉及肝内动脉注射含钇-90的微球。微球主要滞留在肿瘤组织中，从而优先对其进行照射。在该治疗的一项临床试验中，注射微球后能够采集肿瘤和正常肝组织样本，并测量其比活度。然后计算了总共9名患者的肿瘤和正常组织样本的吸收组织辐射剂量。这9名患者的肿瘤与正常组织辐射剂量平均比值约为6:1，范围为0.4:1至45:1。在不同患者中注射相似量的活度会导致组织剂量显著不同，这取决于肝脏大小和肿瘤负荷。测得正常肝组织剂量在9至75 Gy之间，而相应的肿瘤组织剂量范围为34至147 Gy。选择性体内放射治疗与给予血管紧张素II导致的血流变化相结合，能够优先为肝脏内的肿瘤组织提供高辐射剂量，同时相对 sparing周围正常肝组织。 （注：“sparing”可能有误，推测原文是“spare”，意为“使免遭；使幸免” ，这里暂按原文翻译）
