Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Org Lett. 2015 May 15;17(10):2424-7. doi: 10.1021/acs.orglett.5b00935. Epub 2015 Apr 27.
A formal total synthesis of (±)-tetrodotoxin that relies on the bimolecular oxidative amidation of a phenol is described, and a structural correction of the Sato lactone, an important tetrodotoxin intermediate, is provided. This work lays the foundation for an ultimate enantioselective synthesis.
本文描述了一种依赖酚的双分子氧化酰胺化反应的（±）-河豚毒素的全合成方法，并对重要的河豚毒素中间体 Sato 内酯进行了结构修正。这项工作为最终的对映选择性合成奠定了基础。
