[两例伴有抗甲状腺激素自身抗体的格雷夫斯病：甲状腺次全切除术对抗甲状腺激素自身抗体和抗甲状腺球蛋白抗体滴度的影响]

[Two cases of Graves' disease with anti-thyroid hormone autoantibodies: the effect of subtotal thyroidectomy on the titers of anti-thyroid hormone autoantibodies and anti-Tg antibodies].

作者信息

Nagai K, Maekawa H, Kametani M, Tokimitsu N, Komaki T, Kojima N, Sakata S

机构信息

Department of Internal Medicine, Takayama Red Cross Hospital.

出版信息

Nihon Naibunpi Gakkai Zasshi. 1989 Nov 20;65(11):1219-25. doi: 10.1507/endocrine1927.65.11_1219.

DOI:10.1507/endocrine1927.65.11_1219

PMID:2591608

Abstract

We experienced two cases of Graves' disease associated with anti-thyroid hormone autoantibodies (Case 1: anti-T4, Case 2: anti-T3). Both cases underwent subtotal thyroidectomy, and titers of anti-thyroid hormone antibodies and anti-Tg antibodies were compared before and after operation. In case 1, titers of both anti-T4 and anti-Tg antibodies decreased after operation, whereas in Case 2, titers of both anti-T3 and anti-Tg were unchanged before and after operation. There was a significant positive correlation between titers of anti-T4 and anti-Tg antibodies in Case 1 (r = 0.90, P less than 0.01), and anti-T3 and anti-Tg antibodies in Case 2 (r = 0.64, P less than 0.01). These results strengthen the possibility that the antigen of anti-thyroid hormone autoantibodies in both cases is the Tg molecule.

摘要

我们遇到了两例与抗甲状腺激素自身抗体相关的格雷夫斯病（病例1：抗T4，病例2：抗T3）。两例患者均接受了甲状腺次全切除术，并比较了手术前后抗甲状腺激素抗体和抗Tg抗体的滴度。在病例1中，术后抗T4和抗Tg抗体的滴度均下降，而在病例2中，抗T3和抗Tg的滴度在手术前后均未改变。病例1中抗T4和抗Tg抗体的滴度之间存在显著正相关（r = 0.90，P小于0.01），病例2中抗T3和抗Tg抗体之间也存在显著正相关（r = 0.64，P小于0.01）。这些结果增强了两例中抗甲状腺激素自身抗体的抗原均为Tg分子的可能性。