Zhang Dafang, Gao Jie, Li Shu, Wang Fushun, Zhu Jiye, Leng Xisheng
Hepatogastroenterology. 2015 Mar-Apr;62(138):451-4.
BACKGROUND/AIMS: To evaluate short-term outcomes and long-term survival after pancreaticoduodenectomy for malignancy in elderly Chinese patients (aged 70 years or older) compared with younger patients.
Between January 2005 and December 2013, 216 consecutive patients who underwent a PD with pancreatic cancer or periampullary cancers in our institution were recruited in this study. Sixty-eight patients aged 70 years or older when they underwent PD, while 148 patients younger than 70.
There were no significant differences in postoperative mortality (p = 0.104), overall morbidity (p = 0.057) and surgical complications (p = 0.200) between the elderly patients and the younger patients. Elderly patients had a significantly higher incidence of cardiac events (p = 0.008) and pneumonia (p = 0.041) postoperatively. The postoperative hospital stay in the older age group was significantly longer (p = 0.013). The overall survival did not differ between the two age groups both when patients with pancreatic cancer were analyzed (p = 0.836) and when patients with periampullary cancers were analyzed (p = 0.817).
Our results showed that pancreaticoduodenectomy for malignancy in Chinese patients over 70 years old could be performed safely. Age should not be considered as a contraindication to pancreaticoduodenectomy.
背景/目的：评估中国老年患者（70岁及以上）与年轻患者相比，胰十二指肠切除术后的短期结局和长期生存率。
在2005年1月至2013年12月期间，本研究纳入了我院216例连续接受胰腺癌或壶腹周围癌胰十二指肠切除术的患者。68例患者在接受胰十二指肠切除术时年龄在70岁及以上，而148例患者年龄小于70岁。
老年患者与年轻患者在术后死亡率（p = 0.104）、总体发病率（p = 0.057）和手术并发症（p = 0.200）方面无显著差异。老年患者术后心脏事件（p = 0.008）和肺炎（p = 0.041）的发生率显著更高。老年组的术后住院时间明显更长（p = 0.013）。在分析胰腺癌患者时（p = 0.836）和分析壶腹周围癌患者时（p = 0.817），两个年龄组的总生存率无差异。
我们的结果表明，70岁以上中国患者的胰腺癌或壶腹周围癌胰十二指肠切除术可以安全进行。年龄不应被视为胰十二指肠切除术的禁忌证。
