Tomizawa Minoru, Shinozaki Fuminobu, Motoyoshi Yasufumi, Sugiyama Takao, Yamamoto Shigenori, Ishige Naoki
Hepatogastroenterology. 2015 Mar-Apr;62(138):463-5.
BACKGROUND/AIMS: One major problem with Intraductal papillary mucinous neoplasm (IPMN) is the appearance of pancreatic duct adenocarcinoma. Diffusion-weighted whole body imaging with background body signal suppression (DWIBS) provides hyperintense signals in cases of cancer. DWIBS and T2 image fusion (DWIBS/T2) provides functional information in anatomical settings, and is useful for the detection of cancer with strong contrast against surrounding tissues. DWIBS/T2 signals were analyzed in patients with IPMN to investigate positive or negative results.
Patient records were analyzed retrospectively regarding IPMN. None showed high-risk stigmata or worrisome features. To rule out T2 shine-through or differentiate malignant lesions from non-malignant causes of restricted diffusion, positive ADC maps were produced from the recorded ADC values.
None of the patients with IPMN had features of malignant progression. No mural nodules were detected by endoscopic ultrasonography. IPMN was hyperintense with DWIBS/T2 and the ADC map. This finding suggested that the hyperintense values of IPMN were T2 shine-through. These results showed that none of the IPMNs were positive with DWIBS/T2.
DWIBS/T2 was negative for patients with IPMN. DWIBS/T2 might be useful for the evaluation of malignant progression, in addition to observation.
背景/目的：导管内乳头状黏液性肿瘤（IPMN）的一个主要问题是胰腺导管腺癌的出现。背景体素信号抑制的扩散加权全身成像（DWIBS）在癌症病例中提供高信号。DWIBS与T2图像融合（DWIBS/T2）在解剖学背景下提供功能信息，有助于检测与周围组织形成强烈对比的癌症。分析IPMN患者的DWIBS/T2信号以研究阳性或阴性结果。
回顾性分析IPMN患者的病历。均未显示高危特征或可疑特征。为排除T2穿透效应或区分恶性病变与扩散受限的非恶性原因，根据记录的ADC值生成阳性ADC图。
IPMN患者均无恶性进展特征。内镜超声未检测到壁结节。IPMN在DWIBS/T2和ADC图上呈高信号。这一发现提示IPMN的高信号值为T2穿透效应。这些结果表明，IPMN在DWIBS/T2检查中均为阴性。
IPMN患者的DWIBS/T2检查结果为阴性。除观察外，DWIBS/T2可能有助于评估恶性进展。
