Leonova E I, Galzitskaia O V
Mol Biol (Mosk). 2015 Jan-Feb;49(1):89-98.
The famous phrase of F. Engels "Life is the mode of existence of protein bodies", has deeply insinuated itself in our mind. However at a more profound insight, the form of protein bodies is associaited not only with the fact of their existence, but also with the time changes. What unites all of us in our oldage? The answer is clear: it is the change in the way of existence of protein molecules, and more precisely, their uncontrolled aggregation that can take place in any organ and be associated with any protein. In spite of different clinical presentations, all diseases associated with pathological accumulation of aggregated proteins are combined in a general group called amyloisosis. Depen- dent on the place of formation, it is possible to distinguish an infinite number of pathologies from neurodegen- erative and oncologic ones to arthritis and tuberculosis. There is no doubt that provided all clandestine mechanisms are clarified at which an absolutely normal functioning.protein can transform into a pathological aggregated form, it will give us a chance to prevent protein aggregation and create a new form of drugs for prolongation of life. In this review we considered the function of syndecan-2, the structure of syndecan-2 and its role in the formation of amyloid plaques.
恩格斯的名言“生命是蛋白体的存在方式”已深深印刻在我们脑海中。然而，深入洞察会发现，蛋白体的形式不仅与其存在的事实相关，还与时间变化有关。在老年时将我们所有人联系在一起的是什么？答案很明确：是蛋白质分子存在方式的改变，更确切地说，是它们不受控制的聚集，这种聚集可发生在任何器官，并与任何蛋白质相关。尽管临床表现各异，但所有与聚集蛋白病理性积累相关的疾病都归为一类，称为淀粉样变性。根据形成部位的不同，可以区分出无数种病理情况，从神经退行性疾病和肿瘤到关节炎和结核病。毫无疑问，如果所有使完全正常功能的蛋白质转化为病理性聚集形式的隐秘机制都能被阐明，这将给我们提供预防蛋白质聚集的机会，并创造出延长寿命的新型药物。在这篇综述中，我们探讨了syndecan-2的功能、syndecan-2的结构及其在淀粉样斑块形成中的作用。
