Nikitin A G, Potapov V A, Brovkin A N, Lavrikova E Iu, Hodyrev D S, Shamkhalova M Sh, Smetanina S A, Suplotova L N, Shestakova M V, Nosikov V V, Aver'ianov A V
Mol Biol (Mosk). 2015 Jan-Feb;49(1):119-28.
To study the association with diabetes mellitus type 2 we performed anal- ysis of the distribution of frequencies of alleles and genotypes of polymorphic markers of FTO, KCNJ11, SIC30A8 and CDKN2B genes. The study included groups of T2DM patients and unrelated controls of Russian origin. Analysis of the distribution of frequencies of alleles and genotypes of the polymorphic markers of KCNJ11, SLC30A8 and CDKN2B genes showed the presence of association with T2DM in Russian population, while for the FTO gene was not found statistically significant associations with type 2 diabetes. We can conclude that in Russian population main role in the development of type 2 diabetes play genes, affecting the level of syn- thesis and secretion of the insulin in beta-cells of the pancreas.
为了研究与2型糖尿病的关联，我们对FTO、KCNJ11、SLC30A8和CDKN2B基因多态性标记的等位基因和基因型频率分布进行了分析。该研究纳入了俄罗斯裔的2型糖尿病患者组和无关对照组。对KCNJ11、SLC30A8和CDKN2B基因多态性标记的等位基因和基因型频率分布分析表明，在俄罗斯人群中存在与2型糖尿病的关联，而对于FTO基因，未发现与2型糖尿病有统计学意义的关联。我们可以得出结论，在俄罗斯人群中，影响胰腺β细胞胰岛素合成和分泌水平的基因在2型糖尿病的发生中起主要作用。
