Wei Bojun, Shen Hong, Tong Guansheng, Wang Rengui, Chang Hong
Departmen of Otorhinolaryngology Head and Neck Surgery, Beijng Shijitan Hospital, Capital Medical University, Beijing 100038, China. Email:
Departmen of Otorhinolaryngology Head and Neck Surgery, Beijng Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Feb;50(2):123-6.
To evaluate the efficiency of (99)Tc(m)-sestamibi (MIBI) in the diagnosis of parathyroid diseases with primary hyperparathyroidism.
One hundred and four cases with primary hyperparathyroidism underwent MIBI and parathyroidectomy between May 2010 to November 2013 were reviewed. With MIBI, single adenoma was found in 91 cases, two adenomas in 5 cases, carcinoma and hyperplasia in 3 cases respectively. Primary hyperparathyroidism was diagnosed based on the associated symptoms and signs in 93 patients, while it was indicated in 11 asymptomatic patients due to the presence of hypercalcemia in health examination. Parathroid hormone levels ranged from 98 to 2 800 ng/L, and serum calcium levels were between 2.56-4.23 mmol/L.
The sensitivity of MIBI for total diseased parntyroids was 84.0% (100/119), and that for parathyroid adenoma, parnthyroid carcinoma, atypical adenoma and primary parathyroid hyperplasia was 87.1% (88/101), 3/3, 2/2 and 7/13, respectively.
MIBI is efficient in the diagnosis of parathyroid diseases with primary hyperparathyroidism. The size and cystic degeneration of parathroid disease are two common factors decreasing MIBI reliability, and thyroid nodule is additional source leading to false-positive results.
评估99锝-甲氧基异丁基异腈（MIBI）诊断原发性甲状旁腺功能亢进甲状旁腺疾病的效能。
回顾性分析2010年5月至2013年11月期间104例行MIBI检查并接受甲状旁腺切除术的原发性甲状旁腺功能亢进患者。MIBI检查发现91例为单发性腺瘤，5例为双发性腺瘤，3例分别为癌和增生。93例患者根据相关症状和体征诊断为原发性甲状旁腺功能亢进，11例无症状患者因体检发现高钙血症而被诊断。甲状旁腺激素水平为98～2 800 ng/L，血清钙水平为2.56～4.23 mmol/L。
MIBI对全部病变甲状旁腺的敏感度为84.0%（100/119），对甲状旁腺腺瘤、甲状旁腺癌、非典型腺瘤和原发性甲状旁腺增生的敏感度分别为87.1%（88/101）、3/3、2/2和7/13。
MIBI对诊断原发性甲状旁腺功能亢进甲状旁腺疾病有效。甲状旁腺疾病的大小和囊性变是降低MIBI可靠性的两个常见因素，甲状腺结节是导致假阳性结果的额外原因。
