Kiiski Ville, Karlsson Oskar, Remitz Anita, Reitamo Sakari
Department of Dermatology and Venereology, Helsinki University Central Hospital, Skin and Allergy Hospital, FI-00250 Helsinki, Finland.
Acta Derm Venereol. 2015 Nov;95(8):943-7. doi: 10.2340/00015555-2126.
Most patients with severe atopic dermatitis have elevated serum IgE levels, but there has been little research into IgE as a predictive biomarker in long-term disease outcome. The aim of this study was to evaluate the predictive value of IgE and other factors in patients with atopic dermatitis in a university clinic setting. There were 169 eligible patients (14-78 years) with a mean follow-up of 4.15 years. High baseline IgE (≥ 10,000 IU/ml) was the most important patient-related factor for a poor long-term outcome, being negatively associated with good treatment response (odds ratio (OR) 0.062, p = 0.002). Only 14.3% of patients with this high baseline IgE achieved a good treatment response in follow-up, compared with 79.7% in patients with lower (< 1,000) IgE values (p < 0.001). Serum total IgE may provide an easily measurable way to predict long-term outcome, and to help to select those patients in need of closer follow-up.
大多数重度特应性皮炎患者血清IgE水平升高，但关于IgE作为长期疾病预后预测生物标志物的研究很少。本研究旨在评估一所大学诊所环境中特应性皮炎患者IgE及其他因素的预测价值。共有169例符合条件的患者（年龄14 - 78岁），平均随访4.15年。高基线IgE（≥10,000 IU/ml）是长期预后不良最重要的患者相关因素，与良好的治疗反应呈负相关（比值比（OR）0.062，p = 0.002）。随访中，基线IgE高的患者只有14.3%获得了良好的治疗反应，而IgE值较低（<1,000）的患者这一比例为79.7%（p < 0.001）。血清总IgE可能提供一种易于测量的方法来预测长期预后，并有助于选择那些需要密切随访的患者。
