阻止甲基化。
Keeping methylation at bay.
机构信息
Epigenetics Programme, Babraham Institute, Cambridge, UK, and at the Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.
出版信息
Nat Genet. 2015 May;47(5):427-8. doi: 10.1038/ng.3290.
DOI:10.1038/ng.3290
PMID:25916897
Abstract
A hallmark of CpG islands is their unmethylated state, and determining how DNA methylation can invade these elements is therefore important for understanding developmental gene regulation and disease. A new study shows that FBXL10, a protein commonly altered by mutation in leukemia, is part of a mechanism that blocks methylation of CpG islands.
摘要
CpG 岛的一个标志是其非甲基化状态，因此，确定 DNA 甲基化如何侵入这些元件对于理解发育基因调控和疾病非常重要。一项新的研究表明，FBXL10 是一种在白血病中常见突变的蛋白质，是阻止 CpG 岛甲基化的机制的一部分。
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