Lu Chenying, Hui Junguo, Xia Shuiwei, Tu Jianfei, Song Jingjing, Yang Hongyuan, Ji Jiansong
Department of Radiology, No. 5 Affiliated Hospital, Wenzhou Medical University, Lishui Hospital of Zhejiany University, Lishui 323000, China.
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Zhonghua Yi Xue Za Zhi. 2015 Feb 17;95(7):541-3.
To evaluate the diagnostic values of computed tomographic angiography (CTA) for liver VX2 tumor in rabbits.
A total of 40 New Zealand white rabbits were employed by implanting tumor fragment into left liver by computed tomography (CT)-guided percutaneous puncture. And successful modeling was established in 38 rabbits. Plain and three-phase enhanced CT scan and its CTA reconstruction were performed in different stages (14, 21 and 28 days) after tumor implantation, followed by digital subtraction angiography (DSA) via femoral artery and hepatic artery. Dynamic observations of tumor growth characteristics were recorded by plain and enhanced CT and comparing CTA and DSA images. And comparisons of CTA and DSA were made for identifying the origin, course and blood supply of transplanted tumors.
(1) Multi-slice computed tomography (MSCT) could dynamically monitor the growth transfer characteristics. And all tumors became strengthened obviously in arterial phase and washed out in venous and delayed phases. (2) CTA showed that the feeding artery of transplanted tumor was hepatic artery. (3) No obvious differences existed in the display of feeding artery of transplanted tumor between CTA and DSA.However CTA was superior to DSA in displaying three-dimensional structure.
Liver VX2 tumors are hypervascular in rabbits. CT enhanced scanning may dynamically monitor the growth patterns of tumors and CTA is a better method than DSA in visualizing the feeding arteries of tumors. Before and after interventions, CTA may replace DSA in evaluating liver VX2 tumors in rabbits.
评估计算机断层血管造影（CTA）对兔肝VX2肿瘤的诊断价值。
采用40只新西兰白兔，通过计算机断层扫描（CT）引导下经皮穿刺将肿瘤组织块植入左肝。38只兔建模成功。在肿瘤植入后的不同阶段（14、21和28天）进行平扫及三期增强CT扫描及其CTA重建，随后经股动脉和肝动脉行数字减影血管造影（DSA）。通过平扫和增强CT动态观察肿瘤生长特征，并比较CTA和DSA图像。对CTA和DSA进行比较以确定移植瘤的起源、走行和血供。
（1）多层螺旋CT（MSCT）可动态监测肿瘤生长转移特征。所有肿瘤在动脉期明显强化，在静脉期和延迟期呈廓清表现。（2）CTA显示移植瘤的供血动脉为肝动脉。（3）CTA和DSA在显示移植瘤供血动脉方面无明显差异。然而，CTA在显示三维结构方面优于DSA。
兔肝VX2肿瘤血供丰富。CT增强扫描可动态监测肿瘤生长方式，CTA在显示肿瘤供血动脉方面是比DSA更好的方法。在干预前后，CTA在评估兔肝VX2肿瘤方面可替代DSA。
