中国人群阻塞性睡眠呼吸暂停低通气综合征易感基因：21项病例对照研究的荟萃分析
Obstructive sleep apnea syndrome susceptible genes in the Chinese population: a meta-analysis of 21 case-control studies.
作者信息
Lan Fen, Cao Chao, Liu Jinkai, Li Wen
机构信息
Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, College of Medicine and Institute of Respiratory Diseases, Zhejiang University, Hangzhou, 310009, China.
Department of Respiratory Medicine, Affiliated Hospital of School of Medicine, Ningbo University, Ningbo, 315020, China.
出版信息
Sleep Breath. 2015 Dec;19(4):1441-8. doi: 10.1007/s11325-015-1176-0. Epub 2015 Apr 28.
BACKGROUND
Numbers of single nucleotide polymorphisms (SNPs) were identified as risk factors for obstructive sleep apnea syndrome (OSAS) in the Chinese population; however, published articles drew incompatible or even contradictory results.
OBJECTIVE
The aim of this study was to investigate the susceptible SNPs and risk of OSAS in the Chinese population.
METHODS
We conducted a meta-analysis of seven polymorphisms and risk of OSAS based on 21 case-control studies.
RESULTS
The results of our study showed that tumor necrosis factor-α (TNF-α) -308 G/A (OR = 3.70, 95 % CI = 1.39-9.83), gene-linked polymorphic region (LPR) (OR = 0.57, 95 % CI = 0.41-0.79), and variable number tandem repeat (VNTR) of the 5-hydroxytryptamine transporter gene (5-HTT) (OR = 3.44, 95 % CI = 1.49-7.95) polymorphisms were associated with OSAS risk in the Chinese population, while there was no significant association between 5-hydroxytryptamine 2A receptor (5-HTR2A) 102C/T, 5-HTR2A A1438G, angiotensin-converting enzyme (ACE) insertion (I)/deletion (D), or leptin receptor (LEPR)-Gln 223Arg polymorphism and risk of OSAS in the Chinese population.
CONCLUSIONS
Our study demonstrated that TNF-α 308 G/A, 5-HTT LPR, and 5-HTT-VNTR polymorphisms were associated with OSAS risk, whereas little association was observed between 5-HTR2A 102C/T, 5-HTR2A A1438G, ACE I/D, or LEPR-Gln 223Arg polymorphism and risk of OSAS in the Chinese population.
背景
在中国人群中，单核苷酸多态性（SNP）的数量被确定为阻塞性睡眠呼吸暂停综合征（OSAS）的风险因素；然而，已发表的文章得出了不一致甚至相互矛盾的结果。
目的
本研究旨在调查中国人群中OSAS的易感SNP和风险。
方法
我们基于21项病例对照研究对7种多态性与OSAS风险进行了荟萃分析。
结果
我们的研究结果表明，肿瘤坏死因子-α（TNF-α）-308 G/A（比值比[OR]=3.70，95%可信区间[CI]=1.39-9.83）、基因连锁多态性区域（LPR）（OR=0.57，95%CI=0.41-0.79）以及5-羟色胺转运体基因（5-HTT）的可变数目串联重复序列（VNTR）（OR=3.44，95%CI=1.49-7.95）多态性与中国人群的OSAS风险相关，而5-羟色胺2A受体（5-HTR2A）102C/T、5-HTR2A A1438G、血管紧张素转换酶（ACE）插入（I）/缺失（D）或瘦素受体（LEPR）-Gln 223Arg多态性与中国人群的OSAS风险之间无显著关联。
结论
我们的研究表明，TNF-α 308 G/A、5-HTT LPR和5-HTT-VNTR多态性与OSAS风险相关，而在中国人群中，5-HTR2A 102C/T、5-HTR2A A1438G、ACE I/D或LEPR-Gln 223Arg多态性与OSAS风险之间几乎没有关联。
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