Wang Judy, Reiss Kim A, Khatri Rina, Jaffee Elizabeth, Laheru Dan
All authors: Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Sidney Kimmel Cancer Center at The Johns Hopkins University, Baltimore, MD.
All authors: Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Sidney Kimmel Cancer Center at The Johns Hopkins University, Baltimore, MD
J Clin Oncol. 2015 Jun 1;33(16):1745-53. doi: 10.1200/JCO.2015.60.7879. Epub 2015 Apr 27.
The balance between tumor-promoting and tumor-suppressing immune responses and the difference between them ultimately determine whether a cancer escapes immune recognition mechanisms. Defining the complex relationships between the tumor itself, the tumor environment, and the immune system has been critical in facilitating the development of successful immunotherapies. This review explores the role of oncogenes in inducing cancer-associated inflammation, the local and systemic factors that lead to immune suppression, and immunotherapy approaches to overcome immune privilege.
肿瘤促进性免疫反应与肿瘤抑制性免疫反应之间的平衡及其差异最终决定了癌症是否能够逃避免疫识别机制。明确肿瘤自身、肿瘤环境与免疫系统之间的复杂关系对于推动成功的免疫疗法发展至关重要。本综述探讨了癌基因在诱导癌症相关炎症中的作用、导致免疫抑制的局部和全身因素，以及克服免疫豁免的免疫治疗方法。
