Burnett Erin, Loucks Tammy L, Lindsay Michael
Department of Gynecology and Obstetrics, Emory University School of Medicine, 69 Jesse Hill Jr. Drive SE, Glenn Building, 4th Floor, Atlanta, GA 30303, USA.
Infect Dis Obstet Gynecol. 2015;2015:508482. doi: 10.1155/2015/508482. Epub 2015 Mar 31.
To evaluate whether HIV infected pregnant women with concomitant sexually transmitted infection (STIs) are at increased risk of adverse perinatal and neonatal outcomes.
We conducted a cohort study of HIV positive women who delivered at an inner-city hospital in Atlanta, Georgia, from 2003 to 2013. Demographics, presence of concomitant STIs, prenatal care information, and maternal and neonatal outcomes were collected. The outcomes examined were the association of the presence of concomitant STIs on the risk of preterm birth (PTB), postpartum hemorrhage, chorioamnionitis, preeclampsia, intrauterine growth restriction, small for gestational age, low Apgar scores, and neonatal intensive care admission. Multiple logistic regression was performed to adjust for potential confounders.
HIV positive pregnant women with concomitant STIs had an increased risk of spontaneous PTB (odds ratio (OR) 2.11, 95% confidence interval [CI] 1.12-3.97). After adjusting for a history of preterm birth, maternal age, and low CD4+ count at prenatal care entry the association between concomitant STIs and spontaneous PTB persisted (adjusted OR 1.96, 95% CI 1.01-3.78).
HIV infected pregnant women with concomitant STIs relative to HIV positive pregnant women without a concomitant STI are at increased risk of spontaneous PTB.
评估合并性传播感染（STIs）的HIV感染孕妇发生不良围产期和新生儿结局的风险是否增加。
我们对2003年至2013年在佐治亚州亚特兰大市一家市中心医院分娩的HIV阳性女性进行了一项队列研究。收集了人口统计学信息、合并STIs的情况、产前护理信息以及母婴结局。所检查的结局包括合并STIs与早产（PTB）、产后出血、绒毛膜羊膜炎、先兆子痫、胎儿宫内生长受限、小于胎龄儿、低阿氏评分以及新生儿重症监护入院风险之间的关联。进行多因素逻辑回归以调整潜在的混杂因素。
合并STIs的HIV阳性孕妇发生自发性PTB的风险增加（优势比（OR）2.11，95%置信区间[CI] 1.12 - 3.97）。在调整早产史、产妇年龄以及产前护理开始时的低CD4 + 计数后，合并STIs与自发性PTB之间的关联仍然存在（调整后OR 1.96，95% CI 1.01 - 3.78）。
与未合并STIs的HIV阳性孕妇相比，合并STIs的HIV感染孕妇发生自发性PTB的风险增加。
