Wang Ziting, Vathsala Anantharaman, Tiong Ho Yee
Department of Urology, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074.
Division of Nephrology, Department of Medicine, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074 ; National University Centre for Organ Transplantation, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074.
Biomed Res Int. 2015;2015:292034. doi: 10.1155/2015/292034. Epub 2015 Mar 30.
Haematuria has a prevalence of 12% in the postrenal transplant patient population. It heralds potentially dangerous causes which could threaten graft loss. It is important to consider causes in light of the unique, urological, and immunological standpoints of these patients. We review the literature on common causes of haematuria in postrenal transplant patients and suggest the salient approach to the evaluation of this condition. A major cause of haematuria is urinary tract infections. There should be a higher index of suspicion for mycobacterial, fungal, and viral infection in this group of immunosuppressed patients. Measures recommended in the prevention of urinary tract infections include early removal of foreign bodies as well as prophylactic antibiotics during the early transplant phase. Another common cause of haematuria is that of malignancies, in particular, renal cell carcinomas. When surgically managing cancer in the setting of a renal transplant, one has to be mindful of the limited retropubic space and the need to protect the anastomoses. Other causes include graft rejections, recurrences of primary disease, and calculus formation. It is important to perform a comprehensive evaluation with the aid of an experienced multidisciplinary transplant team.
血尿在肾移植术后患者群体中的发生率为12%。它预示着可能存在威胁移植肾丢失的危险病因。从这些患者独特的泌尿学和免疫学角度考虑病因很重要。我们回顾了关于肾移植术后患者血尿常见病因的文献,并提出了评估这种情况的显著方法。血尿的一个主要原因是尿路感染。对于这组免疫抑制患者,应更高程度地怀疑分枝杆菌、真菌和病毒感染。预防尿路感染推荐的措施包括尽早取出异物以及在移植早期使用预防性抗生素。血尿的另一个常见原因是恶性肿瘤,尤其是肾细胞癌。在肾移植情况下进行癌症手术治疗时,必须注意耻骨后间隙有限以及保护吻合口的必要性。其他原因包括移植肾排斥、原发疾病复发和结石形成。借助经验丰富的多学科移植团队进行全面评估很重要。