Tsai Min-Ling, Huang Chien-Ning, Lai Yung-Rung, Chang Horng-Rong, Chiou Jeng-Yuan
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Departments of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan.
Psychogeriatrics. 2016 Mar;16(2):93-101. doi: 10.1111/psyg.12126. Epub 2015 Apr 27.
This study examined the relationship between depression, benzodiazepine (BZD)/nonbenzodiazepine hypnotics (non-BZD), and other risk factors in a national sample of Taiwan's elderly diabetic patients.
Data were drawn from the 2005 Taiwan National Health Interview Survey and adults aged 65 years and older. A total of 1331 subjects were included in this study. The Chinese version of Center for Epidemiologic Studies Depression Scale was used to evaluate patients' depression symptoms.
The rates of depression in the diabetes mellitus (DM) and non-DM groups were 13.5% (39/288) and 9.8% (102/1043) and the average ages were 73.7 and 73.4 years, respectively. In multivariate regression, the odds ratio of depression was 1.66-fold higher among BZD/non-BZD users (95% confidence interval: 1.10-2.51, model 2) than among those without BZD/non-BZD use. In addition, hyperlipidaemia, poor physical function, and antidepressant use were associated with a higher risk of depressive symptoms. Meanwhile, a monthly household income of NT$30 000-NT$49 999, exercise, and betel chewing were associated with a lower risk of depression. We performed an additional logistic analysis for which the odds ratio of depression significantly increased to 1.52 in non-DM elderly patients (95% confidence interval: 1.06-2.19) who were prescribed BZD/non-BZD. In contrast, there was no significant difference in the odds ratio of depression in the DM elderly regardless of BZD/non-BZD use, although there was a slight tendency for depression among those who used BZD/non-BZD.
Depression in non-DM Taiwanese elderly patients was found to be associated with BZD/non-BZD use, whereas depression in DM Taiwanese elderly patients was not found to be associated with BZD/non-BZD use.
本研究在台湾老年糖尿病患者的全国样本中，考察了抑郁症、苯二氮䓬类药物（BZD）/非苯二氮䓬类催眠药（非BZD）及其他风险因素之间的关系。
数据取自2005年台湾国民健康访谈调查，研究对象为65岁及以上的成年人。本研究共纳入1331名受试者。采用中文版流行病学研究中心抑郁量表评估患者的抑郁症状。
糖尿病（DM）组和非DM组的抑郁发生率分别为13.5%（39/288）和9.8%（102/1043），平均年龄分别为73.7岁和73.4岁。在多因素回归分析中，使用BZD/非BZD者患抑郁症的比值比（95%置信区间：1.10 - 2.51，模型2）比未使用BZD/非BZD者高1.66倍。此外，高脂血症、身体功能差及使用抗抑郁药与抑郁症状风险较高相关。同时，家庭月收入新台币30000 - 49999元、运动及嚼槟榔与抑郁风险较低相关。我们进行了一项额外的逻辑回归分析，结果显示，在开具了BZD/非BZD处方的非DM老年患者中，抑郁的比值比显著增至1.52（95%置信区间：1.06 - 2.19）。相比之下，DM老年患者无论是否使用BZD/非BZD，抑郁的比值比均无显著差异，尽管使用BZD/非BZD者有轻微的抑郁倾向。
研究发现，台湾非DM老年患者的抑郁症与使用BZD/非BZD有关，而台湾DM老年患者的抑郁症与使用BZD/非BZD无关。
