血清 copeptin 水平对新诊断高血压患者非勺型血压的预测作用

Serum copeptin levels in predicting nondippers in newly diagnosed hypertension.

作者信息

Uzun Fatih, Biyik Ismail, Akturk Ibrahim F, Yalcin Ahmet A, Erturk Mehmet, Oner Ender, Kalkan Ali K, Yalcin Burce, Atmaca Husnu

机构信息

Departments of aCardiology bMicrobiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul cDepartment of Cardiology, Usak State Hospital Heart Center, Usak dDepartment of Cardiology, Ordu State Hospital, Ordu, Turkey.

出版信息

Blood Press Monit. 2015 Aug;20(4):199-203. doi: 10.1097/MBP.0000000000000123.

DOI:10.1097/MBP.0000000000000123

PMID:25919790

Abstract

OBJECTIVES

The nondipper pattern in hypertension is associated with worse cardiovascular outcomes. In this study, we hypothesized that high copeptin levels could predict nondippers among hypertensive patients and investigated the associations between copeptin levels and nondipper pattern in newly diagnosed hypertensive patients.

METHODS

Ambulatory blood pressure measurements were obtained and the patients were divided into two groups according to ambulatory blood pressure measurement as nondippers and dippers. Serum copeptin levels were measured in addition to routine laboratory investigations. A total of 76 patients were included in the study.

RESULTS

The clinical and laboratory characteristics of the two groups were similar. The mean copeptin values were found to be significantly higher in the nondipper hypertensive group [1.66 (1.19-4.01) and 1.35 (1.12-2.09) IU/ml, respectively, P=0.026]. In the correlation analysis, no correlation was found between copeptin levels and daytime diastolic blood pressure, but there were weak positive correlations with daytime systolic, 24 h systolic, and diastolic blood pressure values (r=0.335, P=0.034, r=0.350, P=0.027, r=0.372, P=0.018, respectively). However, there were significant positive correlations between serum copeptin levels and nocturnal systolic and diastolic blood pressure values (r=0.593, P<0.001, r=0.523, P=0.001, respectively).

CONCLUSION

This study showed that high serum copeptin levels could predict the nondipper pattern in newly diagnosed hypertension.

摘要

目的

高血压患者的非勺型血压模式与更差的心血管结局相关。在本研究中，我们假设高 copeptin 水平可预测高血压患者中的非勺型血压者，并调查新诊断高血压患者中 copeptin 水平与非勺型血压模式之间的关联。

方法

进行动态血压测量，并根据动态血压测量结果将患者分为非勺型血压者和勺型血压者两组。除常规实验室检查外，还测量了血清 copeptin 水平。共有76例患者纳入本研究。

结果

两组的临床和实验室特征相似。发现非勺型高血压组的 copeptin 均值显著更高[分别为 1.66(1.19 - 4.01)和 1.35(1.12 - 2.09)IU/ml，P = 0.026]。在相关性分析中，未发现 copeptin 水平与日间舒张压之间存在相关性，但与日间收缩压、24 小时收缩压和舒张压值存在弱正相关(r = 0.335，P = 0.034；r = 0.350，P = 0.027；r = 0.372，P = 0.018)。然而，血清 copeptin 水平与夜间收缩压和舒张压值之间存在显著正相关(r = 0.593，P < 0.001；r = 0.523，P = 0.001)。