Afsar Baris
Department of Internal Medicine, Nephrology Division, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey.
Suleyman Demirel University, Çünür, Doğu yerleşkesi, Isparta Merkez/Isparta, Postal Code: 32260 Isparta, Turkey.
Clin Hypertens. 2017 Jun 13;23:13. doi: 10.1186/s40885-017-0068-y. eCollection 2017.
Copeptin is derived from the cleavage of the precursor of arginine vasopressin (AVP), produced in an equimolar ratio in hypothalamus and processed during axonal transport AVP is an unstable peptide and has a short half-life of 5-20 min. Unlike AVP, copeptin is a stable molecule and can easily be measured. Recent evidence suggest that increased copeptin levels have been associated with worse outcomes in various clinical conditions including chronic kidney disease (CKD) and hypertension. In this review, the data regarding copeptin with kidney function (evaluated as glomerular filtration rate, increased albumin/protein excretion or both) and hypertension with regard to performed studies, prognosis and pathogenesis was summarised.
copeptin由精氨酸加压素（AVP）前体裂解产生，在下丘脑中以等摩尔比产生，并在轴突运输过程中进行加工。AVP是一种不稳定的肽，半衰期短，为5-20分钟。与AVP不同，copeptin是一种稳定的分子，易于测量。最近的证据表明，在包括慢性肾脏病（CKD）和高血压在内的各种临床情况下，copeptin水平升高与更差的预后相关。在本综述中，总结了关于copeptin与肾功能（以肾小球滤过率、白蛋白/蛋白质排泄增加或两者评估）以及高血压在已开展的研究、预后和发病机制方面的数据。
