母体肥胖对婴儿脑白质发育有负面影响。
Maternal adiposity negatively influences infant brain white matter development.
作者信息
Ou Xiawei, Thakali Keshari M, Shankar Kartik, Andres Aline, Badger Thomas M
机构信息
Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA; Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
出版信息
Obesity (Silver Spring). 2015 May;23(5):1047-54. doi: 10.1002/oby.21055.
OBJECTIVE
To study potential effects of maternal body composition on central nervous system (CNS) development of newborn infants.
METHODS
Diffusion tensor imaging (DTI) was used to evaluate brain white matter development in 2-week-old, full-term, appropriate for gestational age (AGA) infants from uncomplicated pregnancies of normal-weight (BMI < 25 at conception) or obese ( BMI = 30 at conception) and otherwise healthy mothers. Tract-based spatial statistics (TBSS) analyses were used for voxel-wise group comparison of fractional anisotropy (FA), a sensitive measure of white matter integrity. DNA methylation analyses of umbilical cord tissue focused on genes known to be important in CNS development were also performed.
RESULTS
Newborns from obese women had significantly lower FA values in multiple white matter regions than those born of normal-weight mothers. Global and regional FA values negatively correlated (P < 0.05) with maternal fat mass percentage. Linear regression analysis followed by gene ontology enrichment showed that methylation status of 68 CpG sites representing 57 genes with GO terms related to CNS development was significantly associated with maternal adiposity status.
CONCLUSIONS
These results suggest a negative association between maternal adiposity and white matter development in offspring.
目的
研究母体身体成分对新生儿中枢神经系统（CNS）发育的潜在影响。
方法
采用扩散张量成像（DTI）评估来自正常体重（受孕时BMI<25）或肥胖（受孕时BMI = 30）且其他方面健康的母亲的无并发症妊娠的2周龄足月适于胎龄（AGA）婴儿的脑白质发育。基于纤维束的空间统计学（TBSS）分析用于体素水平的分数各向异性（FA）组间比较，FA是白质完整性的敏感指标。还对脐带组织进行了DNA甲基化分析，重点关注已知对CNS发育重要的基因。
结果
肥胖女性的新生儿在多个白质区域的FA值显著低于正常体重母亲的新生儿。整体和区域FA值与母体脂肪质量百分比呈负相关（P<0.05）。线性回归分析及基因本体富集分析表明，代表57个与CNS发育相关的GO术语的68个CpG位点的甲基化状态与母体肥胖状态显著相关。
结论
这些结果表明母体肥胖与后代白质发育之间存在负相关。
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