胡椒酸衍生物的合成及其抗高血脂活性
Synthesis and antihyperlipidemic activity of piperic acid derivatives.
作者信息
A Rong, Bao Narisu, Sun Zhaorigetu, Borjihan Gereltu, Qiao Yanjiang, Jin Zhuang
出版信息
Nat Prod Commun. 2015 Feb;10(2):289-90.
PMID:25920263
Abstract
A series of piperic acid derivatives were designed and synthesized from piperine/piperlonguminine, and their antihyperlipidemic activities evaluated in diet-induced hyperlipidemic rats with respect to simvastatin. Two promising analogues 3 and 10 were discovered and their antihyperlipidemic activities were comparable to or better than those of simvastatin.
摘要
从胡椒碱/荜茇宁设计并合成了一系列胡椒酸衍生物，并在饮食诱导的高脂血症大鼠中相对于辛伐他汀评估了它们的抗高血脂活性。发现了两种有前景的类似物3和10，它们的抗高血脂活性与辛伐他汀相当或更好。
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