Department of Anaesthesia, University of Otago, Christchurch, New Zealand.
Pain Ther. 2015 Jun;4(1):67-87. doi: 10.1007/s40122-015-0036-8. Epub 2015 Apr 29.
A number of studies suggest a link between low levels of 25-hydroxy vitamin D and incidence of acute and chronic pain. Clinical studies of vitamin D supplementation in patients with known vitamin D deficiency have shown mixed results in improving pain scores.
In this article, vitamin D deficiency risk factors are observed and adequate levels of 25-hydroxy vitamin D defined. Clinical supplementation with vitamin D is explored, including the schedules used in published clinical trials. Evidence of the effectiveness of vitamin D supplementation for the treatment of chronic pain conditions from double-blind randomized controlled trials (RCTs) is examined.
The scientific evidence for vitamin D as a treatment option for chronic pain is limited due to lack of RCTs. It cannot be stated conclusively that vitamin D deficiency is directly linked to the etiology or maintenance of chronic pain states.
There remains a growing body of both clinical and laboratory evidence pointing to a potential relationship between low levels of 25-hydroxy vitamin D and a variety of chronic pain states. More focused research involving large RCTs is necessary.
多项研究表明，25-羟维生素 D 水平低与急性和慢性疼痛的发生有关。对已知维生素 D 缺乏症患者进行维生素 D 补充的临床研究显示，在改善疼痛评分方面结果不一。
本文观察了维生素 D 缺乏的危险因素，并确定了 25-羟维生素 D 的适当水平。探讨了维生素 D 的临床补充，包括已发表的临床试验中使用的方案。研究了来自双盲随机对照试验（RCT）的维生素 D 补充治疗慢性疼痛疾病的有效性证据。
由于 RCT 缺乏，维生素 D 作为慢性疼痛治疗选择的科学证据有限。不能确定维生素 D 缺乏与慢性疼痛状态的病因或维持直接相关。
越来越多的临床和实验室证据表明，25-羟维生素 D 水平低与多种慢性疼痛状态之间存在潜在关系。需要进行更有针对性的、涉及大型 RCT 的研究。
