Bernstein Steven L, D'Onofrio Gail, Rosner June, O'Malley Stephanie, Makuch Robert, Busch Susan, Pantalon Michael V, Toll Benjamin
Department of Emergency Medicine, Yale School of Medicine, New Haven, CT; Yale Cancer Center, New Haven, CT.
Department of Emergency Medicine, Yale School of Medicine, New Haven, CT.
Ann Emerg Med. 2015 Aug;66(2):140-7. doi: 10.1016/j.annemergmed.2015.03.030. Epub 2015 Apr 24.
Tobacco use is common among emergency department (ED) patients, many of whom have low income. Our objective is to study the efficacy of an intervention incorporating motivational interviewing, nicotine replacement, and quitline referral for adult smokers in an ED.
This was a 2-arm randomized clinical trial conducted from October 2010 to December 2012 in a northeastern urban US ED with 90,000 visits per year. Eligible subjects were aged 18 years or older, smoked, and were self-pay or had Medicaid insurance. Intervention subjects received a motivational interview by a trained research assistant, 6 weeks' worth of nicotine patches and gum initiated in the ED, a faxed referral to the state smokers' quitline, a booster call, and a brochure. Control subjects received the brochure, which provided quitline information. The primary outcome was biochemically confirmed tobacco abstinence at 3 months. Secondary endpoints included quitline use.
Of 778 enrolled subjects, 774 (99.5%) were alive at 3 months. The prevalence of biochemically confirmed abstinence was 12.2% (47/386) in the intervention arm versus 4.9% (19/388) in the control arm, for a difference in quit rates of 7.3% (95% confidence interval 3.2% to 11.5%). In multivariable logistic modeling controlling for age, sex, and race or ethnicity, study subjects remained more likely to be abstinent than controls (odds ratio 2.72; 95% confidence interval 1.55 to 4.75).
An intensive intervention improved tobacco abstinence rates in low-income ED smokers. Because approximately 20 million smokers, many of whom have low income, visit US EDs annually, these results suggest that ED-initiated treatment may be an effective technique to treat this group of smokers.
急诊科(ED)患者中吸烟现象普遍,其中许多人收入较低。我们的目的是研究一种结合动机访谈、尼古丁替代疗法和戒烟热线转诊的干预措施对急诊科成年吸烟者的疗效。
这是一项双臂随机临床试验,于2010年10月至2012年12月在美国东北部一个每年有90000人次就诊的城市急诊科进行。符合条件的受试者年龄在18岁及以上,吸烟,自费或拥有医疗补助保险。干预组受试者接受由经过培训的研究助理进行的动机访谈,在急诊科开始使用为期6周的尼古丁贴片和口香糖,通过传真转诊至州吸烟者戒烟热线,一次强化电话随访,以及一本宣传册。对照组受试者收到提供戒烟热线信息的宣传册。主要结局是3个月时经生化确认的戒烟情况。次要终点包括戒烟热线的使用情况。
在778名登记受试者中,774名(99.5%)在3个月时存活。干预组经生化确认的戒烟率为12.2%(47/386),对照组为4.9%(19/388),戒烟率差异为 7.3%(95%置信区间3.2%至11.5%)。在控制年龄、性别和种族或族裔的多变量逻辑模型中,研究受试者仍比对照组更有可能戒烟(优势比2.72;95%置信区间1.55至4.75)。
强化干预提高了低收入急诊科吸烟者的戒烟率。由于每年约有2000万吸烟者(其中许多人收入较低)前往美国急诊科就诊,这些结果表明急诊科启动的治疗可能是治疗这组吸烟者的有效技术。