Parsons James T, Greene Bruce D
South Florida Radiation Oncology, Boynton Beach, Florida.
Valley View Hospital, Glenwood Springs, Colorado.
Pract Radiat Oncol. 2015 Sep-Oct;5(5):343-349. doi: 10.1016/j.prro.2015.03.005. Epub 2015 Apr 23.
To review radiation fractionation and chemotherapy trials for patients undergoing organ preservation therapy for locally advanced head and neck squamous cell carcinoma.
Radiation therapy fractionation and chemotherapy trial results as well as historical evidence are systematically reviewed.
Trial results, which involve nearly 30,000 patients, have been interpreted, compared, and presented in a structured manner to demonstrate the changing approaches in treatment over the years from the 1960s to the present. The review includes data from the split-course radiation therapy era, meta-analyses of chemotherapy and radiation therapy fractionation trials, cetuximab trials, "triple-drug trials," and modern trials of induction chemotherapy followed by concomitant chemotherapy and radiation therapy.
This summary will be useful to clinicians making treatment decisions today and to investigators designing trials in the future.
回顾针对局部晚期头颈部鳞状细胞癌接受器官保留治疗患者的放疗分割方案及化疗试验。
系统回顾放疗分割方案及化疗试验结果以及历史证据。
涉及近30000名患者的试验结果已得到解读、比较，并以结构化方式呈现，以展示从20世纪60年代至今多年来治疗方法的变化。该综述包括分段放疗时代的数据、化疗及放疗分割试验的荟萃分析、西妥昔单抗试验、“三联药物试验”以及诱导化疗后序贯同步放化疗的现代试验。
本综述对当今做出治疗决策的临床医生以及未来设计试验的研究人员将有所帮助。
