Liebeskind David S, Feldmann Edward
Neurovascular Imaging Research Core and the University of California, Los Angeles Stroke Center, Los Angeles, California.
Baystate Medical Center, Springfield, Massachusetts.
Ann N Y Acad Sci. 2016 Feb;1366(1):40-8. doi: 10.1111/nyas.12765. Epub 2015 Apr 28.
Imaging of stroke and neurovascular disorders has profoundly enhanced clinical practice and related research during the last 40 years since the introduction of computed tomography (CT) and magnetic resonance imaging (MRI) enabled mapping of the brain. We highlight recent advances in neurovascular imaging. We describe how the convergence of readily available data and new clinical trial paradigms will recast our methods for studying the neurovascular patient. The application of a precision medicine approach to the collaterome, a comprehensive synthesis of neurovascular pathophysiology, will entail novel methods for clinical trial randomization, collection of routine and clinical trial imaging results, data archiving, and analysis.
自从计算机断层扫描（CT）和磁共振成像（MRI）能够对大脑进行成像以来，在过去40年中，中风和神经血管疾病的影像学已经极大地改善了临床实践和相关研究。我们重点介绍神经血管成像的最新进展。我们描述了现有数据和新的临床试验范式的融合将如何重塑我们研究神经血管疾病患者的方法。将精准医学方法应用于侧支循环组学（一种神经血管病理生理学的综合），将需要用于临床试验随机化、常规和临床试验成像结果收集、数据存档及分析的新方法。
