Tavakoli-Ardakani Maria, Mehrpooya Maryam, Mehdizadeh Mahshid, Hajifathali Abbas, Abdolahi Alireza
Department of Clinical Pharmacy, School of pharmacy and Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
School of Pharmacy, Hamedan University of Medical Sciences, Hamedan, Iran.
Int J Hematol Oncol Stem Cell Res. 2015 Apr 1;9(2):80-7.
The release of pro-inflammatory cytokines is responsible for the variety of behavioral, neuro-endocrine and neuro-chemical alterations in psychiatric condition. In this study we evaluate relation between depression and IL-6 and IL-10 in patients undergoing hematopoietic stem cell transplantation (HSCT).
66 patients in this cross-sectional study from July 2013 until August 2014 for HSCT interred the study and were assessed for depression using Hospital Anxiety and Depression Scale (HADS). Serum interleukin (IL)-6, (IL)-10 and high sensitive C-reactive protein (hs-CRP) were assessed on the same time. Association between these biomarkers with depression was evaluated using SPSS version 20.
A total of 66 patients with the mean age of 41.18+13.92 and 41.95+12.35 years old in non depressed and depressed group respectively were enrolled in this study. Patients with depression showed significantly higher levels of serum IL-6 and the IL-6-to-IL-10 ratio compared to patients without depression (p<0.001).There was no statistically significant association between IL-10 and hs-CRP with depression in this group of the patients.
High IL-6 level has significant association with depression in patients undergoing HSCT. In conclusion, since IL-6 can affect the outcomes after HSCT and depression was associated with increased serum IL-6 level, early identification of depression can be beneficial in these patients.
促炎细胞因子的释放导致了精神疾病中各种行为、神经内分泌和神经化学改变。在本研究中，我们评估了接受造血干细胞移植（HSCT）患者的抑郁与白细胞介素-6（IL-6）和白细胞介素-10（IL-10）之间的关系。
在这项横断面研究中，66例于2013年7月至2014年8月接受HSCT的患者纳入研究，并使用医院焦虑抑郁量表（HADS）评估抑郁情况。同时检测血清白细胞介素-6（IL-6）、白细胞介素-10（IL-10）和高敏C反应蛋白（hs-CRP）。使用SPSS 20版评估这些生物标志物与抑郁之间的关联。
本研究共纳入66例患者，非抑郁组和抑郁组的平均年龄分别为41.18±13.92岁和41.95±12.35岁。与非抑郁患者相比，抑郁患者的血清IL-6水平及IL-6与IL-10的比值显著更高（p<0.001）。在该组患者中，IL-10和hs-CRP与抑郁之间无统计学显著关联。
HSCT患者中高IL-6水平与抑郁显著相关。总之，由于IL-6可影响HSCT后的结局，且抑郁与血清IL-6水平升高相关，因此早期识别抑郁对这些患者有益。
