• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

重型地中海贫血和中间型地中海贫血患者左右心容量及功能参数的磁共振比较

Magnetic resonance comparison of left-right heart volumetric and functional parameters in thalassemia major and thalassemia intermedia patients.

作者信息

Liguori Carlo, Pitocco Francesca, Di Giampietro Ilenia, De Vivo Aldo Eros, Schena Emiliano, Giurazza Francesco, Sorrentino Francesco, Zobel Bruno Beomonte

机构信息

Department of Radiology, A.O.R.N. Cardarelli, Via Antonio Cardarelli 9, 80100 Naples, Italy.

Department of Diagnostic Imaging, Campus Bio-Medico University, Via Alvaro del Portillo 200, 00128 Rome, Italy.

出版信息

Biomed Res Int. 2015;2015:857642. doi: 10.1155/2015/857642. Epub 2015 Apr 2.

DOI:10.1155/2015/857642
PMID:25922841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4398923/
Abstract

OBJECTIVES

To evaluate a population of asymptomatic thalassemia major (TM) and thalassemia intermedia (TI) patients using cardiovascular magnetic resonance (CMR). We supposed that TI group could be differentiated from the TM group based on T2(∗) and that the TI group could demonstrate higher cardiac output.

METHODS

A retrospective analysis of 242 patients with TM and TI was performed (132 males, 110 females; mean age 39.6 ± 8 years; 186 TM, 56 TI). Iron load was assessed by T2(∗) measurements; volumetric functions were analyzed using steady-state-free precession sequences.

RESULTS

Significant difference in left-right heart performance was observed between TM with iron overload and TI patients and between TM with iron overload and TM without iron overload (P < 0.05); no significant differences were observed between TM without iron overload and TI patients. A significant correlation was observed between T2(∗) and ejection fraction of right ventricle- (RV-) ejection fraction of left ventricle (LV); an inverse correlation was present among T2(∗) values and end-diastolic volume of LV, end-systolic volume of LV, stroke volume of LV, end-diastolic volume of RV, end-systolic volume of RV, and stroke volume of RV.

CONCLUSIONS

CMR is a leading approach for cardiac risk evaluation of TM and TI patients.

摘要

目的

使用心血管磁共振（CMR）对无症状重型地中海贫血（TM）和中间型地中海贫血（TI）患者群体进行评估。我们推测TI组可基于T2（∗）与TM组区分开来，且TI组可能表现出更高的心输出量。

方法

对242例TM和TI患者进行回顾性分析（男性132例，女性110例；平均年龄39.6±8岁；186例TM，56例TI）。通过T2（∗）测量评估铁负荷；使用稳态自由进动序列分析容积功能。

结果

铁过载的TM患者与TI患者之间以及铁过载的TM患者与无铁过载的TM患者之间，左右心功能存在显著差异（P<0.05）；无铁过载的TM患者与TI患者之间未观察到显著差异。T2（∗）与右心室射血分数-左心室（LV）射血分数之间存在显著相关性；T2（∗）值与LV舒张末期容积、LV收缩末期容积、LV每搏输出量、RV舒张末期容积、RV收缩末期容积和RV每搏输出量之间呈负相关。

结论

CMR是评估TM和TI患者心脏风险的主要方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac1/4398923/ac929bd1be96/BMRI2015-857642.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac1/4398923/01fe97c9ad2a/BMRI2015-857642.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac1/4398923/9e579d16fdb2/BMRI2015-857642.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac1/4398923/ac929bd1be96/BMRI2015-857642.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac1/4398923/01fe97c9ad2a/BMRI2015-857642.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac1/4398923/9e579d16fdb2/BMRI2015-857642.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac1/4398923/ac929bd1be96/BMRI2015-857642.003.jpg

相似文献

1
Magnetic resonance comparison of left-right heart volumetric and functional parameters in thalassemia major and thalassemia intermedia patients.重型地中海贫血和中间型地中海贫血患者左右心容量及功能参数的磁共振比较
Biomed Res Int. 2015;2015:857642. doi: 10.1155/2015/857642. Epub 2015 Apr 2.
2
Magnetic resonance evaluation of liver and myocardial iron deposition in thalassemia intermedia and b-thalassemia major.中间型地中海贫血和重型β地中海贫血患者肝脏及心肌铁沉积的磁共振评估
Int J Cardiovasc Imaging. 2008 Dec;24(8):849-54. doi: 10.1007/s10554-008-9332-2. Epub 2008 Jun 26.
3
Relationship between myocardial T2 values and cardiac volumetric and functional parameters in β-thalassemia patients evaluated by cardiac magnetic resonance in association with serum ferritin levels.心脏磁共振评估β-地中海贫血患者心肌 T2 值与心脏容积和功能参数的关系，并结合血清铁蛋白水平。
Eur J Radiol. 2013 Sep;82(9):e441-7. doi: 10.1016/j.ejrad.2013.03.025. Epub 2013 Apr 29.
4
The relationship between the myocardial T2* value and left ventricular volumetric and functional parameters in thalassemia major patients.地中海贫血症患者心肌 T2* 值与左心室容积和功能参数之间的关系。
Diagn Interv Radiol. 2011 Dec;17(4):346-51. doi: 10.4261/1305-3825.DIR.3933-10.2. Epub 2011 Jun 6.
5
Left and right ventricular function and volume assessment in young thalassemia major patients with no related myocardial iron overload.评估无相关心肌铁过载的年轻重型地中海贫血患者的左、右心室功能和容量。
Ann Hematol. 2012 Dec;91(12):1839-44. doi: 10.1007/s00277-012-1543-x. Epub 2012 Aug 10.
6
Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron.比较无心脏铁沉积的小儿镰状细胞病和重型地中海贫血患者的双心室大小和功能。
Am J Hematol. 2013 Mar;88(3):213-8. doi: 10.1002/ajh.23376. Epub 2013 Feb 6.
7
The efficacy of tissue Doppler imaging in predicting myocardial iron load in patients with beta-thalassemia major: correlation with T2* cardiovascular magnetic resonance.组织多普勒成像预测重型β地中海贫血患者心肌铁负荷的疗效：与 T2*心血管磁共振的相关性。
Int J Cardiovasc Imaging. 2010 Apr;26(4):413-21. doi: 10.1007/s10554-010-9591-6. Epub 2010 Feb 2.
8
Global longitudinal strain by cardiac magnetic resonance is associated with cardiac iron and complications in beta-thalassemia major patients.心脏磁共振测量的整体纵向应变与β-地中海贫血症患者的心脏铁沉积和并发症相关。
Int J Cardiol. 2024 Oct 15;413:132319. doi: 10.1016/j.ijcard.2024.132319. Epub 2024 Jul 5.
9
Echocardiographic finding in beta-thalassemia intermedia and major: absence of pulmonary hypertension following hydroxyurea treatment in beta-thalassemia intermedia.中间型和重型β地中海贫血的超声心动图表现：中间型β地中海贫血患者经羟基脲治疗后无肺动脉高压
Eur J Haematol. 2009 Mar;82(3):213-8. doi: 10.1111/j.1600-0609.2008.01192.x. Epub 2008 Dec 5.
10
Left ventricular rotational dynamics in Beta thalassemia major: a speckle-tracking echocardiographic study.β 地中海贫血症患者左心室旋转动力学：斑点追踪超声心动图研究。
J Am Soc Echocardiogr. 2012 Oct;25(10):1083-90. doi: 10.1016/j.echo.2012.07.007. Epub 2012 Aug 14.

引用本文的文献

1
Prospective Assessment of Cardiac Iron Deposition, Morphology, and Function by Magnetic Resonance Imaging in Non-Transfusion-Dependent and Neo-Transfusion-Dependent Thalassemia.通过磁共振成像对非输血依赖型和新输血依赖型地中海贫血患者心脏铁沉积、形态及功能的前瞻性评估
J Clin Med. 2025 Jun 6;14(12):4020. doi: 10.3390/jcm14124020.
2
Cardiovascular magnetic resonance in β-thalassemia major: beyond T2.重型β地中海贫血的心血管磁共振成像：超越T2加权成像
Radiol Med. 2024 Dec;129(12):1812-1822. doi: 10.1007/s11547-024-01916-6. Epub 2024 Nov 7.
3
Magnetic Resonance Evaluation of Tissue Iron Deposition and Cardiac Function in Adult Regularly Transfused Thalassemia Intermedia Compared with Thalassemia Major Patients.

本文引用的文献

1
Diagnosis and classification of diabetes mellitus.糖尿病的诊断与分类
Diabetes Care. 2014 Jan;37 Suppl 1:S81-90. doi: 10.2337/dc14-S081.
2
Optimal management of β thalassaemia intermedia.β 中间型地中海贫血的最佳管理。
Br J Haematol. 2011 Mar;152(5):512-23. doi: 10.1111/j.1365-2141.2010.08486.x. Epub 2011 Jan 20.
3
Cardiac iron and cardiac disease in males and females with transfusion-dependent thalassemia major: a T2* magnetic resonance imaging study.输血依赖型重型地中海贫血患者的心脏铁与心脏疾病：一项 T2*磁共振成像研究。
与重型地中海贫血患者相比，成人中间型地中海贫血定期输血患者组织铁沉积和心脏功能的磁共振评估
J Clin Med. 2024 Aug 14;13(16):4791. doi: 10.3390/jcm13164791.
4
Multiparametric cardiac magnetic resonance in patients with thalassemia intermedia: new insights from the E-MIOT network.中间型地中海贫血患者的心脏磁共振多参数成像：E-MIOT 网络的新见解。
Radiol Med. 2024 Jun;129(6):879-889. doi: 10.1007/s11547-024-01821-y. Epub 2024 Apr 29.
5
Phenotypic Clustering of Beta-Thalassemia Intermedia Patients Using Cardiovascular Magnetic Resonance.利用心血管磁共振成像对中间型β地中海贫血患者进行表型聚类分析
J Clin Med. 2023 Oct 24;12(21):6706. doi: 10.3390/jcm12216706.
6
Left Ventricular Myocardial Dysfunction Evaluation in Thalassemia Patients Using Echocardiographic Radiomic Features and Machine Learning Algorithms.超声心动图放射组学特征和机器学习算法在铁过载患者左心室心肌功能障碍评估中的应用。
J Digit Imaging. 2023 Dec;36(6):2494-2506. doi: 10.1007/s10278-023-00891-0. Epub 2023 Sep 21.
7
Cardiovascular magnetic resonance native T and T quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis.心肌病和心脏移植的心血管磁共振原生T和T定量值：系统评价和荟萃分析。
J Cardiovasc Magn Reson. 2020 May 11;22(1):34. doi: 10.1186/s12968-020-00627-x.
8
Pulmonary hypertension associated with thalassemia syndromes.地中海贫血综合征相关的肺动脉高压
Ann N Y Acad Sci. 2016 Mar;1368(1):127-39. doi: 10.1111/nyas.13037. Epub 2016 Mar 23.
Haematologica. 2011 Apr;96(4):515-20. doi: 10.3324/haematol.2010.025510. Epub 2011 Jan 12.
4
Preferential patterns of myocardial iron overload by multislice multiecho T*2 CMR in thalassemia major patients.地贫患者多层多回波 T*2 CMR 评估心肌铁过载的优势模式。
Magn Reson Med. 2010 Jul;64(1):211-9. doi: 10.1002/mrm.22410.
5
Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload.无心肌铁过载的重型地中海贫血患者的右心室容量和功能。
J Cardiovasc Magn Reson. 2010 Apr 23;12(1):24. doi: 10.1186/1532-429X-12-24.
6
Relation of myocardial T2* to right ventricular function in thalassaemia major.铁过载对重型β地中海贫血患者右心室功能的影响
Eur Heart J. 2010 Jul;31(13):1648-54. doi: 10.1093/eurheartj/ehq106. Epub 2010 Apr 22.
7
Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major.心脏T2*磁共振成像预测重型地中海贫血患者心脏并发症的研究
Circulation. 2009 Nov 17;120(20):1961-8. doi: 10.1161/CIRCULATIONAHA.109.874487. Epub 2009 Oct 2.
8
Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance.英国重型地中海贫血患者生存率的提高及其与T2*心血管磁共振成像的关系
J Cardiovasc Magn Reson. 2008 Sep 25;10(1):42. doi: 10.1186/1532-429X-10-42.
9
Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction.重型地中海贫血联合螯合疗法治疗重度心肌铁沉着症伴左心室功能障碍。
J Cardiovasc Magn Reson. 2008 Feb 25;10(1):12. doi: 10.1186/1532-429X-10-12.
10
Diagnosis and management of transfusion iron overload: the role of imaging.输血性铁过载的诊断与管理：影像学的作用
Am J Hematol. 2007 Dec;82(12 Suppl):1132-5. doi: 10.1002/ajh.21099.