在锁骨上臂丛神经阻滞期间，将纳洛酮添加到布比卡因或布比卡因 - 芬太尼中可延长运动和感觉阻滞时间：一项随机临床试验。

Naloxone added to bupivacaine or bupivacaine-fentanyl prolongs motor and sensory block during supraclavicular brachial plexus blockade: a randomized clinical trial.

作者信息

Marashi S M, Sharifnia H R, Azimaraghi O, Aghajani Y, Barzin G, Movafegh A

机构信息

Department of Anesthesiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Acta Anaesthesiol Scand. 2015 Aug;59(7):921-7. doi: 10.1111/aas.12527. Epub 2015 Apr 29.

DOI:10.1111/aas.12527

PMID:25922978

Abstract

BACKGROUND

In this study, the effect of naloxone on duration of supraclavicular brachial plexus block was evaluated. It was hypothesized that naloxone can increase the duration of neural blockade.

METHODS

Sixty-eight patients scheduled for surgery under supraclavicular brachial plexus block were randomly assigned to receive 30 ml bupivacaine (Group C); 30 ml bupivacaine with 100 μg of fentanyl (Group F); 30 ml bupivacaine with 100 ng naloxone (Group N); or 30 ml bupivacaine with 100 μg of fentanyl and 100 ng naloxone (Group N + F). Sensory and motor blockade were recorded at 5, 15, and 30 min following the block, and every 10 min following the end of surgery. Duration of sensory and motor block was considered to be the time interval between the complete block and the first postoperative pain and complete recovery of motor functions.

RESULTS

Sensory and motor onset times were the same in all groups. The duration of sensory and motor block in Group C (11.3 ± 1.7 h and 4.56 ± 1.0 h) and Group F (12.8 ± 3.3 h and 5.1 ± 2.0 h) were less than in the other groups (18.1 ± 2.2 h and 6.18 ± 1.0 h in Group N, and 15.8 ± 2.9 h and 6.53 ± 1.1 h in Group N + F, P < 0.0001).

CONCLUSION

Addition of naloxone to bupivacaine in supraclavicular brachial plexus block prolonged the duration of the neural blockade.

摘要

背景

在本研究中，评估了纳洛酮对锁骨上臂丛神经阻滞持续时间的影响。研究假设是纳洛酮可延长神经阻滞的持续时间。

方法

68例计划行锁骨上臂丛神经阻滞下手术的患者被随机分为四组，分别接受30毫升布比卡因（C组）；30毫升布比卡因加100微克芬太尼（F组）；30毫升布比卡因加100纳克纳洛酮（N组）；或30毫升布比卡因加100微克芬太尼和100纳克纳洛酮（N+F组）。在阻滞完成后5、15和30分钟以及手术结束后每10分钟记录感觉和运动阻滞情况。感觉和运动阻滞的持续时间被认为是从完全阻滞到术后首次疼痛和运动功能完全恢复之间的时间间隔。

结果

所有组的感觉和运动起效时间相同。C组（感觉阻滞11.3±1.7小时，运动阻滞4.56±1.0小时）和F组（感觉阻滞12.8±3.3小时，运动阻滞5.1±2.0小时）的感觉和运动阻滞持续时间短于其他组（N组感觉阻滞18.1±2.2小时，运动阻滞6.18±1.0小时；N+F组感觉阻滞15.8±2.9小时，运动阻滞6.53±1.1小时，P<0.0001）。