Wang Tao, Liu LuHao, Luo JinTai, Liu TaiSheng, Wei AnYang
Department of Urology, Medical Center for Overseas Patients, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Urology, Minimally Invasive Surgery Center, the First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology, Guangzhou, China.
Urol J. 2015 Apr 29;12(2):2057-64.
There are many recent observational studies on testicular microlithiasis (TM) and risk of testicular cancer. Whether TM increases the risk of testicular cancer is still inconclusive. The objective of this updated meta-analysis was to synthesize evidence from clinical observational studies that evaluated the association between TM and testicular cancer.
We identified eligible studies by searching the PubMed, Embase and Cochrane Library before March 2014. Adjusted relative risks (RR) with 95% confidence interval (CI) were calculated using random-or fixed-model.
A total of 14 studies involving 35,578 participants were included in the meta-analysis. On the basis of the Newcastle Ottawa Scale systematic review, eleven studies were identified as relatively high-quality. TM was strong association with an increased incidence of testicular cancer (RR = 12.70, 95% CI: 8.18-19.71, P < .001), with significant evidence of heterogeneity among these studies (P for heterogeneity < .001, I2 = 82.1%). The subgroup and sensitivity analysis confirmed the stability of the results and no publication bias was detected.
The present meta-analysis suggests that TM is significantly associated with risk of testicular cancer. More researches are warranted to clarify an understanding of the association between TM and risk of testicular cancer.
近期有许多关于睾丸微石症（TM）与睾丸癌风险的观察性研究。TM是否会增加睾丸癌风险仍无定论。这项更新的荟萃分析的目的是综合来自评估TM与睾丸癌之间关联的临床观察性研究的证据。
我们通过检索2014年3月之前的PubMed、Embase和Cochrane图书馆来确定符合条件的研究。使用随机或固定模型计算调整后的相对风险（RR）及95%置信区间（CI）。
荟萃分析共纳入14项研究，涉及35578名参与者。根据纽卡斯尔渥太华量表系统评价，11项研究被确定为质量相对较高。TM与睾丸癌发病率增加有很强的关联（RR = 12.70，95% CI：8.18 - 19.71，P <.001），这些研究之间有显著的异质性证据（异质性P <.001，I² = 82.1%）。亚组和敏感性分析证实了结果的稳定性，未检测到发表偏倚。
目前的荟萃分析表明，TM与睾丸癌风险显著相关。需要更多的研究来阐明对TM与睾丸癌风险之间关联的理解。
