Venugopal P, Rajni A, Gopal R, Nair C N, Kurkure P A, Saikia T K, Nadkarni K S, Pai S K, Pai V R, Advani S H
J Assoc Physicians India. 1989 Jun;37(6):367-70.
Fifty patients of multiple myeloma have been studied. Seventy eight per cent of the patients were in the 5th, 6th and 7th decades of life. Commonest presenting feature was bone pains (76%). 8%, 20% belonged to stage I, II and III respectively. Skull (58%), ribs (52%) and pelvis (24%) were most commonly involved. Immunoelectrophoresis revealed IgG type of myeloma in 76% and IgA type in 10% cases. Bence-Jones proteinuria was seen in 60% of patients; Kappa specificity was commoner than lambda. Overall survival at 30 months was 50%. The survival was adversely influenced by advanced stage, higher plasma cell count in the bone marrow, low haemoglobin and high serum creatinine values.
对50例多发性骨髓瘤患者进行了研究。78%的患者年龄在50至70岁之间。最常见的临床表现是骨痛（76%）。分别有8%、20%的患者属于Ⅰ期、Ⅱ期和Ⅲ期。最常受累的部位是颅骨（58%）、肋骨（52%）和骨盆（24%）。免疫电泳显示，76%的病例为IgG型骨髓瘤，10%为IgA型。60%的患者出现本周蛋白尿；κ轻链比λ轻链更常见。30个月时的总生存率为50%。晚期、骨髓浆细胞计数较高、血红蛋白水平低和血清肌酐值高对生存率有不利影响。
