Chen Hong, Ge Lin, Sui Qiuli, Lin Mei
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, PR China.
Department of Oral medicine, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, PR China.
PLoS One. 2015 Apr 29;10(4):e0123347. doi: 10.1371/journal.pone.0123347. eCollection 2015.
To evaluate the association between the EPHX1 Tyr113His and His139Arg polymorphisms in the EPHX1 gene and the risk of head and neck cancer.
Studies on the association of EPHX1 Tyr113His and His139Arg polymorphisms with HNC performed up until June 1st, 2014, were identified using a predefined search strategy. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of these associations.
In this meta-analysis, 10 case-control studies, which included 9 studies of Tyr113His (1890 cases and 1894 controls) and 10 studies of His139Arg polymorphisms (1982 cases and 2024 controls), were considered eligible for inclusion. Overall, the pooled results indicated that the EPHX1 Tyr113His polymorphism was significantly associated with increased HNC risk (Tyr/His vs. Tyr/Tyr, OR = 1.26, 95%1.02-1.57;His/His+ Tyr/His vs. Tyr/Tyr, OR = 1.29, 95% I = 1.03-1.61). However, no significant association was found between the His139Arg polymorphism and HNC risk. In the subgroup analysis, a statistically significant association between the EPHX1 Tyr113His polymorphism and HNC was observed in population-based case-control studies (PCC), which involved less than 500 participants and genotype frequencies in HWE. This association showed minimal heterogeneity after excluding studies that were determined to contribute to heterogeneity. After categorizing the studies by publication time, a sensitivity analysis and cumulative meta-analysis of the two associations were conducted, and the results of the two analyses were consistent.
Our meta-analysis suggests that EPHX1 Tyr113His polymorphism may be a risk factor for HNC, while the EPHX1 His139Arg polymorphism has no association with HNC risk.
评估EPHX1基因中EPHX1 Tyr113His和His139Arg多态性与头颈癌风险之间的关联。
采用预定义的检索策略，识别截至2014年6月1日进行的关于EPHX1 Tyr113His和His139Arg多态性与头颈癌关联的研究。汇总比值比（OR）和95%置信区间（CI）用于评估这些关联的强度。
在这项荟萃分析中，10项病例对照研究被认为符合纳入标准，其中包括9项关于Tyr113His的研究（1890例病例和1894例对照）以及10项关于His139Arg多态性的研究（1982例病例和2024例对照）。总体而言，汇总结果表明EPHX1 Tyr113His多态性与头颈癌风险增加显著相关（Tyr/His vs. Tyr/Tyr，OR = 1.26，95%CI = 1.02 - 1.57；His/His + Tyr/His vs. Tyr/Tyr，OR = 1.29，95%CI = 1.03 - 1.61）。然而，未发现His139Arg多态性与头颈癌风险之间存在显著关联。在亚组分析中，在基于人群的病例对照研究（PCC）中观察到EPHX1 Tyr113His多态性与头颈癌之间存在统计学显著关联，这些研究涉及不到500名参与者且基因型频率处于哈迪-温伯格平衡（HWE）。在排除被确定为导致异质性来源的研究后，这种关联显示出最小的异质性。按发表时间对研究进行分类后，对这两种关联进行了敏感性分析和累积荟萃分析，两种分析结果一致。
我们的荟萃分析表明，EPHX1 Tyr113His多态性可能是头颈癌的一个风险因素，而EPHX1 His139Arg多态性与头颈癌风险无关。
