从波兰南部尿路感染患者中分离出的铜绿假单胞菌的毒力和抗生素耐药性

Virulence and Antibiotic Resistance of Pseudomonas aeruginosa Isolated from Patients with Urinary Tract Infections in Southern Poland.

作者信息

Pobiega Monika, Wojkowska-Mach Jadwiga, Maciag Joanna, Chmielarczyk Agnieszka, Romaniszyn Dorota, Pomorska-Wesolowska Monika, Ziolkowski Grzegorz, Heczko Piotr B, Bulanda Malgorzata

机构信息

Department of Microbiology, Jagiellonian University Medical College, Krakow, Poland.

出版信息

Chemotherapy. 2014;60(4):253-60. doi: 10.1159/000376569. Epub 2015 Apr 25.

DOI:10.1159/000376569

PMID:25925894

Abstract

BACKGROUND

The aim of this study was to analyze the resistance and virulence of Pseudomonas aeruginosa strains causing urinary tract infections in in- and outpatients in Southern Poland.

METHODS

The study included 83 inpatients and 66 outpatients; 36.9% were female.

RESULTS

Monomicrobial infections accounted for 74.5%; polymicrobial infections occurred more frequently among inpatients (odds ratio, OR = 4.32, p = 0.0008). exoS and lasB were detected in 90 and 74% of isolates, respectively. aprA was present in 66%, pilB in 5% and pilA in 23% of isolates. Isolates from adults were more frequently resistant to fluoroquinolones (OR = 0.37, p = 0.029). Twenty-nine isolates were classified as multidrug resistant and 12 as extremely drug resistant, which occurred less frequently in patients <17 years (OR = 0.18, p = 0.024). Nine metallo-β-lactamase-positive isolates were identified. blaSHV was present in 10, blaTEM in 6, blaOXA-10 in 3 and blaVIM-2 in 3 isolates.

CONCLUSION

Antibiotic selection should be based on the knowledge of local antimicrobial susceptibilities to maximize the benefit for patients and minimize the risk of drug resistance.

摘要

背景

本研究旨在分析波兰南部引起住院患者和门诊患者尿路感染的铜绿假单胞菌菌株的耐药性和毒力。

方法

该研究纳入了83名住院患者和66名门诊患者；36.9%为女性。

结果

单一微生物感染占74.5%；多重微生物感染在住院患者中更常见（优势比，OR = 4.32，p = 0.0008）。分别在90%和74%的分离株中检测到exoS和lasB。66%的分离株中存在aprA，5%中存在pilB，23%中存在pilA。成人分离株对氟喹诺酮类药物的耐药性更高（OR = 0.37，p = 0.029）。29株分离株被归类为多重耐药，12株为极耐药，在<17岁患者中出现的频率较低（OR = 0.18，p = 0.024）。鉴定出9株金属β-内酰胺酶阳性分离株。10株分离株中存在blaSHV，6株中存在blaTEM，3株中存在blaOXA - 10，3株中存在blaVIM - 2。