Akiyoshi Takuyu, Ogawa Sumito, Akishita Masahiro
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Japan.
Clin Calcium. 2015 May;25(5):671-7.
Vascular calcification is a risk factor for cerebral and cardiovascular events and has a high prevalence among elderly. To finding ways of prevent or cure vascular calcification may leads to not only a healthy longevity but also medical expenditure reduction. However, the molecular mechanism underlying this pathogenic process is still obscure. To clarify the mechanism of vascular calcification, the development of animal models that exhibit extensive and robust vascular calcification is an important issue for research in vascular biology.
血管钙化是脑卒中和心血管事件的危险因素，在老年人中具有很高的患病率。寻找预防或治疗血管钙化的方法不仅可能带来健康长寿，还能降低医疗费用。然而，这一致病过程的分子机制仍不清楚。为了阐明血管钙化的机制，建立表现出广泛而强烈血管钙化的动物模型是血管生物学研究的一个重要问题。
