Lughezzani Giovanni, Buffi Nicoló Maria
Department of Urology, Istituto Clinico Humanitas, Rozzano, Italy.
Asian J Androl. 2015 Sep-Oct;17(5):769-70. doi: 10.4103/1008-682X.151394.
Prostate cancer (PCa) represents the most common malignancy in adult males with an estimated number of 280 000 newly diagnosed cases only in the United States in 2015. [1] Due to the introduction of PSA in clinical practice, the majority of the patients are currently diagnosed with organ-confined and sometimes indolent disease. However, a nonnegligible proportion of individuals are still diagnosed with locally-advanced tumors. In their recently published article, Bekelman et al. [2] focused on elderly patients with locally-advanced PCa in the attempt to determine the best treatment approach in this patient category, and concluded that, even in these individuals, androgen deprivation therapy (ADT) plus radiotherapy (RT) may confer a survival benefit relative to ADT alone. The importance of the current article resides in the fact that it focuses on a patient population that has not been, or has been only scarcely, included in previous studies on the same topic.
前列腺癌（PCa）是成年男性中最常见的恶性肿瘤，据估计，仅在2015年美国就有28万例新诊断病例。[1] 由于前列腺特异性抗原（PSA）在临床实践中的应用，目前大多数患者被诊断为器官局限性疾病，有时甚至是惰性疾病。然而，仍有不可忽视比例的个体被诊断为局部晚期肿瘤。在他们最近发表的文章中，贝克尔曼等人[2] 关注老年局部晚期前列腺癌患者，试图确定这类患者的最佳治疗方法，并得出结论，即使在这些个体中，雄激素剥夺疗法（ADT）加放射疗法（RT）相对于单纯ADT可能带来生存益处。本文的重要性在于它关注的是一个在以前关于同一主题的研究中未被纳入或很少被纳入的患者群体。
