Reinhardt W, Appel M C, Alex S, Yang Y N, Braverman L E
Department of Medicine, University of Massachusetts Medical School, Worcester 01655.
J Endocrinol Invest. 1989 Sep;12(8):559-63. doi: 10.1007/BF03350760.
The BB/Wor rat spontaneously develops autoimmune insulin dependent diabetes mellitus and lymphocytic thyroiditis (LT). Excess iodine ingestion enhances and low iodine diet decreases the incidence of LT in this rat model but does not affect the incidence of diabetes mellitus. The administration of a low dose of methimazole (MMI; 870 ng/gm bw ip daily) from 30-90 days of age had no significant effect on thyroid function or on the incidence of iodine induced LT and serum anti-thyroglobulin (Tg) antibodies measured by an ELISA assay. A large dose of MMI (0.05% in the drinking water) induced goiter and hypothyroidism. In addition, the incidence of LT was markedly attenuated (76% vs 6%, p less than 0.001) and reduced titers of serum anti-Tg antibodies (0.59 +/- 0.1 OD vs 0.08 +/- 0.01, p less than 0.001) were observed. This inhibitory effect of MMI on the occurrence of iodine induced LT in the BB/Wor rat may be due to the lower antigenicity of the poorly iodinated Tg secondary to MMI therapy and/or to an immunosuppressant effect of MMI itself.
BB/Wor大鼠会自发发展为自身免疫性胰岛素依赖型糖尿病和淋巴细胞性甲状腺炎（LT）。在该大鼠模型中，过量摄入碘会增加LT的发病率，而低碘饮食则会降低其发病率，但对糖尿病的发病率没有影响。从30至90日龄开始每天腹腔注射低剂量甲巯咪唑（MMI；870 ng/g体重），对甲状腺功能、碘诱导的LT发病率以及通过ELISA测定的血清抗甲状腺球蛋白（Tg）抗体均无显著影响。大剂量MMI（饮用水中含0.05%）会诱发甲状腺肿和甲状腺功能减退。此外，LT的发病率显著降低（76%对6%，p<0.001），血清抗Tg抗体滴度也降低（0.59±0.1 OD对0.08±0.01，p<0.001）。MMI对BB/Wor大鼠碘诱导的LT发生的这种抑制作用可能是由于MMI治疗后碘化不足的Tg抗原性降低和/或MMI本身的免疫抑制作用。
