Nasredinov A S, Anisimov S V, Vavilov V N, Puzanov M V, Kurapeev D I
Tsitologiia. 2014;56(12):926-32.
Small diameter tissue engineered vascular grafts could be a potential solution to the shortage of vascular substitutes in reconstructive cardiovascular surgery. Previously, we have developed a decellularization method for human umbilical arteries, which could be used as a scaffold in vascular tissue engineering. Objective of the study was to optimize the recellelularization of decellularized scaffolds with mesenchymal stem cells. In the study, the possibility of cell growth on decellularized vessel has been shown. We also has proved that the use of perfusion-bioreactor improves the results of recellularization.
小直径组织工程血管移植物可能是解决重建心血管手术中血管替代物短缺问题的一种潜在方法。此前，我们已开发出一种用于人脐动脉的去细胞化方法，该方法可作为血管组织工程中的支架。本研究的目的是优化用间充质干细胞对去细胞化支架进行再细胞化的过程。在该研究中，已证明细胞在去细胞化血管上生长的可能性。我们还证明了使用灌注生物反应器可改善再细胞化的效果。
