Schick J B, Beck A L, DeSilva H N
Department of Pediatrics, Saint Frances Hospital and Medical Center, Hartford, Connecticut 06105.
J Perinatol. 1989 Dec;9(4):382-5.
A historical cohort study was designed to examine high (T6-T11) versus low (L3-L5) umbilical artery catheter (UAC) positioning as a risk factor for subependymal/intraventricular hemorrhage (SEH/IVH) in very low birthweight infants. High and low UAC groups were similar for mode of delivery, severity of pulmonary disease, weight, gestation, Apgar scores, and air leak. Seventeen of 36 infants with high UACs and 6 of 44 infants with low UACs developed SEH/IVH. The incidence (P less than .001) and severity (P less than .01) of SEH/IVH was significantly greater in the high UAC positioning group. Retrograde arterial flow with or without embolization to the cerebral circulation from high UAC positioning is suggested as a possible cause for the association between high UAC positioning and SEH/IVH.
一项历史性队列研究旨在探讨极低出生体重儿中，脐动脉导管（UAC）置于高位（T6-T11）与低位（L3-L5）作为室管膜下/脑室内出血（SEH/IVH）危险因素的情况。UAC高位组和低位组在分娩方式、肺部疾病严重程度、体重、孕周、阿氏评分和气漏方面相似。36例UAC置于高位的婴儿中有17例发生SEH/IVH，44例UAC置于低位的婴儿中有6例发生SEH/IVH。UAC置于高位组的SEH/IVH发生率（P<0.001）和严重程度（P<0.01）显著更高。UAC置于高位导致的逆行动脉血流伴或不伴脑循环栓塞被认为是UAC置于高位与SEH/IVH之间关联的可能原因。
