Kawczyk-Krupka Aleksandra, Bugaj Andrzej M, Latos Wojciech, Zaremba Katarzyna, Wawrzyniec Katarzyna, Sieroń Aleksander
School of Medicine with the Division of Dentistry in Zabrze, Department and Clinic of Internal Diseases, Angiology and Physical Medicine in Bytom, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland.
School of Medicine with the Division of Dentistry in Zabrze, Department and Clinic of Internal Diseases, Angiology and Physical Medicine in Bytom, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland; College of Health, Beauty Care and Education, Brzeźnicka Street 3, 60-133 Poznań, Poland.
Photodiagnosis Photodyn Ther. 2015 Sep;12(3):545-53. doi: 10.1016/j.pdpdt.2015.04.004. Epub 2015 Apr 27.
Photodynamic therapy (PDT) is used in many different oncologic fields. Also in gastroenterology, where have been a few attempts to treat both the premalignant lesion and advanced colorectal cancer. This review aims to give a general overview of the PDT application to colorectal cancer in the field of clinical trials to emphasize its curative, and insufficiently exploited potential.
Literature on PDT for colorectal cancer with the following medical subject headings search terms: colorectal cancer, photodynamic therapy, clinical trials was reviewed. The articles were selected by their relevance to the topic.
There are many positive and promising trial results from I to II/III phase for the use of PDT in colorectal cancer both in less advanced tumors as well as in the palliative therapy of advanced lesions.
PDT seems to be a safe and a feasible treatment option for colorectal cancer. Theoretical assumptions confirmed by many results of preclinical studies taking into consideration an increasing number of analyzed clinical trials, should lead to the development of optimized standards by using PDT in colorectal cancer treatment.
光动力疗法（PDT）应用于许多不同的肿瘤学领域。在胃肠病学领域也有一些尝试，用于治疗癌前病变和晚期结直肠癌。本综述旨在对临床试验领域中PDT在结直肠癌中的应用进行总体概述，以强调其治愈潜力以及尚未得到充分利用的潜力。
对以下医学主题词搜索词的关于结直肠癌光动力疗法的文献进行了综述：结直肠癌、光动力疗法、临床试验。根据文章与主题的相关性进行筛选。
从I期到II/III期，在进展较缓的肿瘤以及晚期病变的姑息治疗中，使用PDT治疗结直肠癌都有许多积极且有前景的试验结果。
PDT似乎是结直肠癌一种安全可行的治疗选择。考虑到越来越多的临床研究结果，许多临床前研究的理论假设得到证实，这应该会促使在结直肠癌治疗中使用PDT制定优化标准。
